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Region Hovedstaden - en del af Københavns Universitetshospital

Information processing in schizophrenia: A longitudinal study of first-episode, antipsychotic-naïve schizophrenia patients

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Schizophrenia is a pathogenically and pathophysiologically complex disorder with unsatisfying treatment results. Many studies have primarily focused on the clinical diagnosis rather than intermediate phenotypes,so called endophenotypes that are directly related to the pathophysiology. Endophenotypes are measurable, genetically determined markers of a disease and are therefore relevant targets for neurobiologically valid interventions. Deficits in information processing are core features in the pathophysiology of schizophrenia.
These deficits can be quantified by means of psychophysiological and neurocognitive methodology. Impairments in the early processing of information, including impaired filtering or “gating” of information, are considered
to be candidate endophenotypes in schizophrenia. Previous data on the effect of atypical antipsychotics on deficits in those processes of information processing known as “sensorimotor gating” and “sensory gating” have been contradictory. Furthermore, most studies have been comparative studies on chronic
patients in whom the pathophysiology is likely to have been modified by previous medication and the course of illness.
The primary objectives of the present PhD study was to investigate deficits in the processing of information in antipsychotic-naïve first-episode schizophrenia patients measured by psychophysiological methods reflecting sensorimotor gating (prepulse inhibition of the startle reflex (PPI)), habituation, sensitization and sensory gating (P50 suppression), and to evaluate the effect of six months treatment with the atypical antipsychotic quetiapine on these psychophysiological measures. Secondary objectives were to examine the relationship
between selected psychopathological and neurocognitive measures and the psychophysiological measures of information processing. Thirty-four antipsychotic-naïve patients and 34 healthy controls were tested with a psychophysiological test battery and a comprehensive neurocognitive test battery at baseline.
Following this, the patients were treated with quetiapine for a period of six months after which both patients and matched controls were re-tested. A total of 19 patients completed the study.
FinansieringskildeAnden offentlig støtte (Offentlig)
ForskningsprogramPHD støtte

ID: 32283071