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Region Hovedstaden - en del af Københavns Universitetshospital

Infections and neuroinflammation as risk factors for mental disorders - PhD project

Projekt: Typer af projekterProjekt

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The overall aim of the thesis was to investigate if infections and neuroinflammation are associated with mental disorders by conducting both population-based studies and systematic reviews and meta-analyses. The field of immunopsychiatry is growing but still only little is truly understood about this possible association.

Specific aims
Paper I
To conduct a systematic review and meta-analysis of clinical studies with analyses of immunological alterations in the cerebrospinal fluid (CSF) of individuals with mental disorders.

Paper II
To examine the association between immunological CSF abnormalities as possible signs of neuroinflammation and the development of mental disorders by conducting a register-based study assessing CSF tests performed in the Central Denmark Region.

Paper III
To examine the Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) hypothesis by investigating the association between throat infections caused by group A beta-hemolytic streptococcal (GAS) bacteria and the risk of mental disorders, in a population-based cohort study including the entire Danish population.

Paper IV
To further investigate the PANDAS hypothesis by conducting a systematic review and meta-analysis of clinical, longitudinal studies with PANDAS cases and controls.


  • Sundhedsvidenskab - Anxiety Disorders, Mood Disorders, Neurocognitive/Organic Disorders, Neurodevelopmental Disorders, Schizophrenia Spectrum and Other Psychotic Disorders, Suicide, Biomarkers, Cognition, Epidemiologic, Genetic Techniques, Neuroimaging, Registerbased research, Meta-Analysis, Observational Study

ID: 61941370