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Region Hovedstaden - en del af Københavns Universitetshospital

Identifying Minimal Cognitive Decline in Aging

Projekt: Typer af projekterProjekt

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This project is part of a larger birth cohort study on healthy aging. The project is part of CESA (Center for Sund Aldring/Healthy Aging) at the Clinical Neurophysiological Department, Glostrup Hospital. The affiliation to CINS is with Senior Scientist, Ph.D. Birgitte Fagerlund, who supervises the new neurocognitive assessments in the study.

Project description: This is a small part of a large study on healthy aging, in which subjects are recruited from the Copenhagen Aging and Midlife Biobank (CAMB), which is being established at the Department for Public Health at Copenhagen University between 2009-2011, and in which 18.500 subjects will be invited to participate. The subjects that are recruited from CAMB will all be male subjects that are also part of the Metropolit cohort, which contains data on all males born in the Copenhagen Catchment Area in 1953. Measures of intelligence were carried out when these subjects were age 12, and again as part of their (obligatory) army recruitment assessment at age 18/19. As part of the CAMB study, intelligence will again be assessed in 2009-2011. A regression model on the first 500 CAMB subjects will help determine the current predicted level of cognitive function based on the previous intelligence tests carried out at age 12 and age 18/19. From this group of 500 subjects, 210 subjects will be identified as having either the highest or lowest residuals, or in the middle (70 subjects in each group). These subjects will participate in a large examination programme (most of which is beyond the current scope), but which also includes new neurocognitive assessments, using the CANTAB battery (which is also used in almost all of the other cognitive studies in CINS). Only this new neurocognitive part of the study is affiliated with CINS.



  • Sundhedsvidenskab - Neurocognitive/Organic Disorders, Cognition, Observational study

ID: 32283363