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Region Hovedstaden - en del af Københavns Universitetshospital

Differences in inflammation and microbiota in pUC and aUC - a prospective study

Projekt: Typer af projekter

  1. Se-Calprotectin

    Projekt: Typer af projekter

  2. IBD og Mikrobiom

    Projekt: Typer af projekter

  3. Vitamin D og IBD

    Projekt: Typer af projekter

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Ulcerative colitis (UC) is an inflammatory bowel disease characterised by continuously inflammation of the colon accompanied by bloody stools. Of unknown reasons, children have a more aggressive disease course than adults. 70-90% of children will present with pancolitis as opposed to 20-30% in adults. Moreover, children will more often experience disease flairs and receive corticosteroids, immunosuppressants, and biological treatment, than adult patients with UC.
This ph.d aims to decipher the differences in the inflammatory profiles in paediatric (pUC) and adult (aUC) UC. Our working hypothesis is, that pUC and aUC have different inflammatory profiles regarding histology, miRNA, and microbiota. Moreover, we postulate that patients diagnosed with UC during childhood have an increased likelihood of developing cancer.
To elucidate these hypotheses we will initiate three studies. A population-based study to describe the differences in disease course between pUC and aUC in the era of biological treatment, a prospective clinical study to examine the inflammation and microbiota, and an international population-based study to assess cancer incidence and risk factors for developing cancer.
The outcome of this study will increase the physicians’ possibilities in tailoring the correct medication in UC and focusing the cancer surveillance programs to those patients at risk of developing cancer.
StatusIgangværende
Periode12/06/201701/06/2020

ID: 50597087