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Region Hovedstaden - en del af Københavns Universitetshospital

BOND: Birth with Oxytocin and Normal and abnormal Development

Projekt: Typer af projekterProjekt

  • Lønfeldt, Nicole Nadine (Projektleder, faglig)
  • Plessen , Kerstin J (Projektdeltager)
  • Lebowitz, Eli, Yale University, USA (Projektdeltager)
  • Strandberg-Larsen, Katrine, Københavns Universitet, Danmark (Projektdeltager)
  • Verhulst, Frank (Projektdeltager)
  • Munk-Olsen, Trine, Danmark (Projektdeltager)
  • Smith-Nielsen, Johanne, Danmark (Projektdeltager)
  • Skovgaard Væver, Mette, Danmark (Projektdeltager)
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Background: The oxytocinergic system (OT-system) plays a critical role in anxiety and mood regulation and maternal bonding. Therefore, it is plausible that if obstetric synthetic oxytocin (synOT) dysregulates the OT-system of mothers or children, it can have adverse effects on anxiety and mood regulation and maternal bonding. Objective: We will examine whether synOT use is associated with problematic maternal bonding, postpartum depression symptoms and diagnosis, child internalizing symptoms and diagnoses (anxiety and depression). Methods: The studies outlined in the proposal will be conducted using Danish registry data and the Danish National Birth Cohort (DNBC). In Part 1 of the study, we will link registry data with data from the DNBC. We will investigate if there are associations between obstetric synOT and impaired maternal bonding (attachment representations and behaviors), maternal depression and anxiety symptoms, and infant incessant crying (emotion dysregulation) and cautious mood and behavior at 6 and 8 months postpartum. In Part 2 of the study, we will compare mothers and children who received synOT during birth using Danish registry data. We will follow children from their 1st birthday until an internalizing disorder diagnosis, death, immigration, or Dec. 31, 2016. Mothers will be followed from when they give birth until a depressive, anxiety or stress disorder, death, immigration or their child's 1st birthday. Other means of labor induction, analgesic use, birth complications, cesarean section, gestational age, birth weight, birth year, gender and parental history of psychiatric illness will be controlled for. Potential implications: Results from this project will allow obstetric professionals to make more informed decisions about the use of synOT and generate new knowledge about OT's role in socioemotional development.


  • Sundhedsvidenskab - Anxiety Disorders, Mood Disorders, Behavioral, emotional disorders onset child/adolescence, Epidemiologic, Registerbased research, Observational study, Meta-Analysis

ID: 62375734