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Region Hovedstaden - en del af Københavns Universitetshospital

ASEP: Adverse somatic events and disorders following psychotropic medication

Projekt: Typer af projekterProjekt

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Intro: There is an international trend for increasing prescriptions of psychotropic medication in the treatment of child and adolescent psychiatric disorders. So far, adverse events of psychotropic medications have been studied predominantly in open clinical studies or randomized controlled trials (RCT) with rather small samples and mostly relatively short observation periods. Furthermore, there is a concerning lack of knowledge on adverse events in medicated youth since most of the studies have been dealing with adult samples only. Studies based on data from the Danish registries will allow the analysis of adverse events in large representative cohorts of all ages over a rather long observation period. This project will look at the associations of major psychotropic medication groups and long-term adverse events in terms of somatic disorders and symptoms in patients treated for mental disorders aged 6-28 years. Major psychotropic medications to be studied will include antipsychotics, antidepressants, anxiolytics, stimulants, and mood stabilizers.
Methods: The index groups to be studied will include all children, adolescents, and adults (6-28 years) at the time of their first prescription of psychotropic medications for any mental disorder in the period 1995-2019. Index groups in terms of specific psychotropic medications and subgroups reflecting the type of mental disorder, certain age-groups (youth vs. adults), and sex will be focused upon. In addition, control groups from the general population matched by date of birth and sex to the index individuals will be studied. Control individuals have to be alive and free from any psychiatric disorder at the time of the first psychiatric diagnosis of the index individuals. For each index individual there will be up to 10 control individuals. The first study will address the association of antipsychotics and adverse events by examining predominantly cardiovascular and metabolic events and disorders (e.g., ischemic and hypertensive heart disease, myocardial infarction, angina pectoris, stroke, obesity, diabetes mellitus). The entire project will control for the following co-variates: mental disorders (classified according to ICD-8 and ICD-10 criteria and collected in the DPCRR), familial risk of mental and physical illnesses, and patient history of medical illnesses.
Results (expected): The findings of the project will be published in a series of papers in major international psychiatric journals of high quality standard.
Discussion/Impact (expected): This project will provide much needed information on the frequency and risks of various major somatic adverse events in youth in an area that has been very much neglected by past research. The findings will also provide chances to tailor prevention programs so that serious adverse effects associated with long-term psychotropic medication may potentially be reduced or avoided.


  • Sundhedsvidenskab - Anxiety Disorders, Disruptive, impulsive control, and conduct disorders, Mood Disorders, Neurodevelopmental Disorders, Schizophrenia Spectrum and Other Psychotic Disorders, Epidemiologic, Pharmacology, Registerbased research

ID: 61843295