Personlig profil
Kort præsentation
As a part of Copenhagen Hepatitis C Program (CO-HEP), my research is affiliated with Department of Immunology and Microbiology, University of Copenhagen as well as Department of Infectious Disease and Clinical Research Centre, Hvidovre Hospital.
My research focus, however, is broader than just hepatitis C virus
(HCV) and its homologs, but also includes how RNA viruses in general interact with cellular RNA during infection. The exciting overlapping field of cellular non-coding RNA and virology allows for application of state-of-the art systems biology techniques in the context of viral infection an approach that reveals phenomena that would otherwise be missed using reductionist approaches.
My research interest is focused on the biology of viral infections.
Only through establishing detailed functional knowledge on the virus and its interaction with the host can we learn how to prevent and treat infectious disease. With a background in hepatitis C virus (HCV), it has been exciting to follow how 25 years of basic research have paved the way for novel therapies currently coming to the clinic.
In particular, I am interested in the molecular biology of RNA viruses and their interplay with host RNA. Previous and ongoing projects include the interactions between viruses and miRNAs, miRNA systems biology, functional and therapeutic studies of HCV, molecular evolution of RNA viruses, development of in vivo infectious clones and cell culture systems for cultivation of viruses, RNA virus recombination and novel animal homologue viruses of HCV.
I welcome any interest in becoming a member of the group or in collaborations.
Expertise
My research interest is focused on the biology of viral infections. Only through establishing detailed functional knowledge on the virus and its interaction with the host can we learn how to prevent and treat infectious disease. With a background in hepatitis C virus (HCV), it has been exciting to follow how 25 years of basic research have paved the way for novel therapies currently coming to the clinic. In particular, I am interested in the molecular biology of RNA viruses and their interplay with host RNA. Previous and ongoing projects include the interactions between viruses and miRNAs, miRNA systems biology, functional and therapeutic studies of HCV, molecular evolution of RNA viruses, development of in vivo infectious clones and cell culture systems for cultivation of viruses, RNA virus recombination and novel animal homologue viruses of HCV. The exciting overlapping field of cellular non-coding RNA and virology allows for application of state-of-the art systems biology techniques in the context of viral infection an approach that reveals phenomena that would otherwise be missed using reductionist approaches.
As a part of Copenhagen Hepatitis C Program (CO-HEP), my research is affiliated with Department of Immunology and Microbiology, University of Copenhagen as well as Department of Infectious Disease, and Clinical Research Centre, Hvidovre Hospital.
I welcome any interest in becoming a member of the group or in collaborations.
Fingeraftryk
- 1 Lignende profiler
Samarbejde og topforskningsområder i de sidste fem år
Publikation
-
In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus
Thorselius, C. E., Kok, A., Fahnøe, U., Wolfisberg, R., Kennedy, M. J., Lundsgaard, E. A., Mikkelsen, L., Larsen, M. K., Murthy, S., Trivedi, S., Kapoor, A., Scheel, T. K. H., Holmbeck, K. & Bukh, J., sep. 2025, I: PLOS Pathogens. 21, 9, e1013127.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Norway rat hepacivirus resembles hepatitis C virus in terms of intra-host evolution and escape from neutralizing antibodies
Thorselius, C. E., Wolfisberg, R., Fahnøe, U., Scheel, T. K. H., Holmbeck, K. & Bukh, J., 2025, I: Journal of Hepatology. 83, 4, s. 870-880 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
2 Citationer (Scopus) -
Animal hepacivirus models for hepatitis C virus immune responses and pathology
Kennedy, M. J., Fernbach, S. & Scheel, T. K. H., jul. 2024, I: Journal of Hepatology. 81, 1, s. 184-186 3 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
4 Citationer (Scopus) -
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Brown, A. J., Won, J. J., Wolfisberg, R., Fahnøe, U., Catanzaro, N., West, A., Moreira, F. R., Nogueira Batista, M., Ferris, M. T., Linnertz, C. L., Leist, S. R., Nguyen, C., De la Cruz, G., Midkiff, B. R., Xia, Y., Evangelista, M. D., Montgomery, S. A., Billerbeck, E., Bukh, J. & Scheel, T. K. H. & 2 flere, , 1 jan. 2024, I: Hepatology (Baltimore, Md.). 79, 1, s. 183-197 15 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
13 Citationer (Scopus) -
JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in the evaluation of virus neutralization
Collignon, L., Holmbeck, K., Just, A., Verhoye, L., Velázquez-Moctezuma, R., Fahnøe, U., Carlsen, T. H. R., Law, M., Prentoe, J., Scheel, T. K. H., Gottwein, J. M., Meuleman, P. & Bukh, J., 1 nov. 2024, I: Hepatology (Baltimore, Md.). 80, 5, s. 1227-1238 12 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
5 Citationer (Scopus)