Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J-M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & Gottwein, J. M., sep. 2019, I : Hepatology (Baltimore, Md.). 70, 3, s. 771-787 17 s.

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HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

Pham, L. V., Jensen, S. B., Fahnøe, U., Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez, S., Humes, D., Serre, S. B. N., Schønning, K., Bukh, J. & Gottwein, J. M., 1 mar. 2019, I : Journal of Hepatology. 70, 3, s. 388-397 10 s.

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Hepatitis C Virus Genotype 1-6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness and Resistance Patterns in the Context of the Infectious Viral Life Cycle

Serre, S. B. N., Brun Jensen, S., Ghanem, L., Humes, D. G., Ramirez, S., Li, Y-P., Krarup, H., Bukh, J. & Gottwein, J. M., jun. 2016, I : Antimicrobial Agents and Chemotherapy. 60, 6, s. 3563-3578

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Substitutions at Hepatitis C Virus Genotypes 2-6 NS3 Residues 155, 156, or 168 Induce Complex Patterns of Protease Inhibitor Resistance

Brun Jensen, S., Serre, S. B. N., Humes, D. G., Ramirez, S., Li, Y-P., Bukh, J. & Gottwein, J. M., dec. 2015, I : Antimicrobial Agents and Chemotherapy. 59, 12, s. 7426-7436

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Differential Sensitivity of 5'UTR-NS5A Recombinants of Hepatitis C Virus Genotypes 1-6 to Protease and NS5A Inhibitors

Li, Y-P., Ramirez, S., Humes, D., Brun Jensen, S., Gottwein, J. M. & Bukh, J., mar. 2014, I : Gastroenterology. 146, 3, s. 812-821 10 s.

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Highly efficient infectious cell culture of three HCV genotype 2b strains and sensitivity to lead protease, NS5A, and polymerase inhibitors

Ramirez, S., Li, Y-P., Brun Jensen, S., Pedersen, J., Gottwein, J. M. & Bukh, J., feb. 2014, I : Hepatology. 59, 2, s. 395-407 13 s.

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Combination treatment with HCV protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a and 3a virus

Gottwein, J. M., Brun Jensen, S., Li, Y., Ghanem, L., Scheel, T. K. H., Serre, S. B. N., Mikkelsen, L. & Bukh, J., mar. 2013, I : Antimicrobial Agents and Chemotherapy. 57, 3, s. 1291-1303 13 s.

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Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

Li, Y-P., Ramirez, S., Brun Jensen, S., Purcell, R. H., Gottwein, J. M. & Bukh, J., 2012, I : Proceedings of the National Academy of Sciences of the United States of America.

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