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Region Hovedstaden - en del af Københavns Universitetshospital

Peter Østrup Jensen

(Tidligere)

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Expertise

Function of neutrophils; Effect of host response on the microenvironment during infection; Effect of host response on the life style of pathogenic bacteria; Effect of the life style of bacteria on the activity of antibiotics; Biochemical explanation of the bactericidal activity of antibiotics

Primære forskningsområder

Polymorphonuclear leukocytes (PMNs) direct adaptation by shaping the chemical microenvironment of infections .  PMNs accelerate O2 depletion and Pseudomonas aeruginosa adapts by employing anaerobic respiration in lung secretions from cystic fibrosis patients with chronic P. aeruginosa pneumonia. 
Therefore, I focus on the importance of O2 depletion for microbial  pathogenicity, activity of antibiotics, and host response in inflammations involving PMNs.

Aktuel forskning

At present I aim to enhance the bactericidal activity of antibiotics on bacterial biofilm by reoxygenation.

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