Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation: In memoriam Professor Niels Borregaard

Theilgaard-Mönch, K., Pundhir, S., Reckzeh, K., Su, J., Tapia, M., Furtwängler, B., Jendholm, J., Jakobsen, J. S., Hasemann, M. S., Knudsen, K. J., Cowland, J. B., Fossum, A., Schoof, E., Schuster, M. B. & Porse, B. T., 23 jun. 2022, I: Nature Communications. 13, 1, s. 3595

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Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML

Pfeiffer, A., Franciosa, G., Locard-Paulet, M., Piga, I., Reckzeh, K., Vemulapalli, V., Blacklow, S. C., Theilgaard-Mönch, K., Jensen, L. J. & Olsen, J. V., 6 jun. 2022, I: Cancer Research. 82, 11, s. 2141-2155 15 s.

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Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML

Centio, A., Estruch, M., Reckzeh, K., Sanjiv, K., Vittori, C., Engelhard, S., Warpman Berglund, U., Helleday, T. & Theilgaard-Mönch, K., 4 maj 2022, I: Molecular Cancer Therapeutics. 21, 5, s. 703-714 12 s.

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TET2 deficiency cooperates with CBFB-MYH11 to induce acute myeloid leukaemia and represents an early leukaemogenic event

Reckzeh, K., Estruch, M., Ali, M., Søgaard Helbo, A., Mosbech, A., Jae Won, K., Rücker, F., Döhner, K. & Theilgaard-Mönch, K., apr. 2022, I: British Journal of Haematology. 197, 2, s. 201-206 6 s.

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Psychotropic Drug Use in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndrome (MDS): A Danish Nationwide Matched Cohort Study of 2404 AML and 1307 MDS Patients

Jensen, O., Øvlisen, A. K., Jakobsen, L. H., Roug, A. S., Nielsen, R. E., Marcher, C. W., Ebbesen, L. H., Theilgaard-Mönch, K., Møller, P., Schöllkopf, C., Torp-Pedersen, C., El-Galaly, T. C. & Severinsen, M. T., 2022, I: Clinical Epidemiology. 14, s. 225-237 13 s.

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The EHA Research Roadmap: Normal Hematopoiesis

Jaffredo, T., Balduini, A., Bigas, A., Bernardi, R., Bonnet, D., Canque, B., Charbord, P., Cumano, A., Delwel, R., Durand, C., Fibbe, W., Forrester, L., de Franceschi, L., Ghevaert, C., Gjertsen, B., Gottgens, B., Graf, T., Heidenreich, O., Hermine, O., Higgs, D. & 21 flere, Kleanthous, M., Klump, H., Kouskoff, V., Krause, D., Lacaud, G., Celso, C. L., Martens, J. H. A., Méndez-Ferrer, S., Menendez, P., Oostendorp, R., Philipsen, S., Porse, B., Raaijmakers, M., Robin, C., Stunnenberg, H., Theilgaard-Mönch, K., Touw, I., Vainchenker, W., Corrons, J-L. V., Yvernogeau, L. & Schuringa, J. J., dec. 2021, I: HemaSphere. 5, 12, 9 s., e669.

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MTH1 inhibitor TH1579 induces oxidative DNA damage and mitotic arrest in acute myeloid leukemia

Sanjiv, K., Calderón-Montaño, J. M., Pham, T. M., Erkers, T., Tsuber, V., Almlöf, I., Höglund, A., Heshmati, Y., Seashore-Ludlow, B., Nagesh Danda, A., Gad, H., Wiita, E., Göktürk, C., Rasti, A., Friedrich, S., Centio, A., Estruch, M., Våtsveen, T. K., Struyf, N., Visnes, T. & 12 flere, Scobie, M., Koolmeister, T., Henriksson, M., Wallner, O., Sandvall, T., Lehmann, S., Theilgaard-Mönch, K., Garnett, M. J., Östling, P., Walfridsson, J., Helleday, T. & Warpman Berglund, U., 15 nov. 2021, I: Cancer Research. 81, 22, s. 5733-5744 12 s.

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Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance

Alrich, M. E., Vittori, C., Muños-Montesinos, T., Reckzeh, K. & Theilgaard-Mönch, K., 10 nov. 2021, I: Cancer Drug Resistance. 4, 4, s. 984-995 12 s.

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Treatment intensity and survival trends among real-world elderly AML patients diagnosed in the period 2001-2016: a Danish nationwide cohort study

Naur, T. M. H., Jakobsen, L. H., Roug, A. S., El-Galaly, T. C., Marcher, C. W., Nørgaard, J. M., Theilgaard-Mönch, K., Møller, P., Schöllkopf, C. & Severinsen, M. T., aug. 2021, I: Leukemia and Lymphoma. 62, 8, s. 2014-2017 4 s.

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Novel Combination Treatments for AML

Alrich, M. E., Vittori, C., Muños-Montesinos, T., Reckzeh, K. & Theilgaard-Mönch, K., 26 jul. 2021, I: Journal of Cellular Immunology. s. 240 245 s.

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Targeted inhibition of cooperative mutation- and therapy-induced AKT activation in AML effectively enhances response to chemotherapy

Estruch, M., Reckzeh, K., Vittori, C., Centio, A., Ali, M., Engelhard, S., Zhao, L., Won, K. J., Liu, P., Porse, B. T. & Theilgaard-Mönch, K., jul. 2021, I: Leukemia. 35, 7, s. 2030-2042 13 s.

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The prognostic impact of anthropometrics in acute myeloid leukemia treated with intensive chemotherapy - A Danish nationwide cohort study

Kristensen, D., Nielsen, L. B., Roug, A. S., Kristensen, T-C. C., Heath, A., Jacobsen, L. H., Nørgaard, J. M., Jepsen, L. Ø., Schöllkopf, C., Theilgaard-Mönch, K. & Severinsen, M. T., jul. 2021, I: Leukemia Research. 106, 106567.

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Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study

Hjort Jakobsen, L., Roug, A. S., Kiesbye Øvlisen, A., Werenberg Marcher, C., Beier Ommen, H., Theilgaard-Mönch, K., Møller, P., Schöllkopf, C., Kristensen, D., Maria Henriette Naur, T., Bøgsted, M., Christoffer El-Galaly, T. & Tang Severinsen, M., maj 2021, I: British Journal of Haematology. 193, 3, s. 482-487 6 s.

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The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study

Kristensen, D., Nielsen, L. B., Roug, A. S., Kristensen, T-C. C., El-Galaly, T. C., Nørgaard, J. M., Marcher, C. W., Schöllkopf, C., Theilgaard-Mönch, K. & Severinsen, M. T., 21 apr. 2020, I: British Journal of Haematology. 190, 2, s. 236-243 8 s.

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Identification of two distinct pathways of human myelopoiesis

Drissen, R., Thongjuea, S., Theilgaard-Mönch, K. & Nerlov, C., 24 maj 2019, I: Nature Immunology. 4, 35, eaau7148.

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Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

Jakobsen, J. S., Laursen, L. G., Schuster, M. B., Pundhir, S., Schoof, E., Ge, Y., d'Altri, T., Vitting-Seerup, K., Rapin, N., Gentil, C., Jendholm, J., Theilgaard-Mönch, K., Reckzeh, K., Bullinger, L., Döhner, K., Hokland, P., Fitzgibbon, J. & Porse, B. T., 1 jan. 2019, I: Scientific American. 5, 7, s. eaaw4304

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Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

Reckzeh, K., Kizilkaya, H., Helbo, A. S., Alrich, M. E., Deslauriers, A. G., Grover, A., Rapin, N., Asmar, F., Grønbæk, K., Porse, B., Borregaard, N., Vestweber, D., Nerlov, C. & Theilgaard-Mönch, K., 10 jul. 2018, I: Blood advances. 2, 13, s. 1628-1632 5 s.

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Low-molecular-weight carbohydrate Pentaisomaltose may replace dimethyl sulfoxide as a safer cryoprotectant for cryopreservation of peripheral blood stem cells

Svalgaard, J. D., Haastrup, E. K., Reckzeh, K., Holst, B., Glovinski, P. V., Gørløv, J. S., Hansen, M. B., Moench, K. T., Clausen, C. & Fischer-Nielsen, A., maj 2016, I: Transfusion. 56, 5, s. 1088-95 8 s.

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ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

Knudsen, K. J., Rehn, M. C., Hasemann, M. S., Rapin, N., Bagger, F. O., Ohlsson, E., Willer, A., Frank, A. K., Søndergaard, E., Jendholm, J., Thorén, L., Lee, J., Rak, J., Theilgaard-Mönch, K. & Porse, B. T., 15 sep. 2015, I: Genes & Development. 29, 18, s. 1915-29 15 s.

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Cellular origin of prognostic chromosomal aberrations in AML patients

Mora-Jensen, H., Jendholm, J., Rapin, N., Andersen, M. K., Roug, A. S., Bagger, F. O., Bullinger, L., Winther, O., Borregaard, N., Porse, B. T. & Theilgaard-Mönch, K., 2015, I: Leukemia. 29, 8, s. 1785-1789

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Comparing cancer vs. normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

Rapin, N., Bagger, F. O., Jendholm, J., Mora-Jensen, H., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Mönch, K. & Porse, B. T., 2014, I: Blood. 123, 6, s. 894-904

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Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177

Hu, N., Mora-Jensen, H., Theilgaard-Mönch, K., Doornbos-van der Meer, B., Huitema, M. G., Stegeman, C. A., Heeringa, P., Kallenberg, C. G. M. & Westra, J., 2014, I: P L o S One. 9, 6, s. e99671

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HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

Bagger, F. O., Rapin, N., Theilgaard-Mönch, K., Kaczkowski, B., Thoren, L. A., Jendholm, J., Winther, O. & Porse, B. T., 2013, I: Nucleic Acids Research. 41, Database issue, s. D1034-9

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MicroRNA profiling in human neutrophils during bone marrow granulopoiesis and in vivo exudation

Larsen, M. T., Hother, C., Häger, M., Pedersen, C. C., Theilgaard-Mönch, K., Borregaard, N. & Cowland, J. B., 2013, I: P L o S One. 8, 3, s. e58454

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HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

Bagger, F. O., Rapin, N., Theilgaard-Mönch, K., Kaczkowski, B., Jendholm, J., Winther, O. & Porse, B., 2012, I: Blood. 119, 26, s. 6394-5 2 s.

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Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency

Hasemann, M. S., Schuster, M. B., Frank, A-K., Theilgaard-Mönch, K., Pedersen, T., Nerlov, C. & Porse, B. T., 2012, I: P L o S One. 7, 6, s. e38841

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Gene expression profiling in MDS and AML: potential and future avenues

Theilgaard-Mönch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J. M., Kohlmann, A., Morgan, M., Porse, B. T., Tagliafico, E., Zwaan, C. M., Wainscoat, J., Van den Heuvel-Eibrink, M. M., Mills, K. & Bullinger, L., 2011, I: Leukemia. 25, 6, s. 909-20 12 s.

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NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

Weischenfeldt, J., Damgaard, I., Bryder, D., Theilgaard-Mönch, K., Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C. & Porse, B. T., 15 maj 2008, I: Genes and Development. 22, 10, s. 1381-1396 16 s.

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