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Region Hovedstaden - en del af Københavns Universitetshospital

Jane Alrø Bøtkjær


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On the basis of my master in molecular biomedicine I have a broad knowledge and experience with the various techniques used for molecular diagnostics.

Primære forskningsområder

Reproductive science with focus on molecular mechanisms involved in the female reproductive system.

Aktuel forskning

The aim of my PhD project is to enhance the knowledge of mechanisms that are essential to female fertility. More specifically the project focuses on regulation of Insulin-like Growth Factor (IGF) activity within female reproductive organs with special emphasis on Pregnancy-Associated Plasma Protein-A (PAPP-A). Single nucleotide polymorphisms (SNPs) in the PAPP-A gene that are associated with adverse pregnancy outcome are analyzed. I will evaluate how these genetic variations affect human ovarian follicular function, and thereby deduce whether genetic variations may or may not influence the female fertility. Evaluation of a possible association between these SNPs and recurrent pregnancy loss will be performed. Further, gene expression levels from isolated stage-specific human follicles will be studied with focus on genes related to the IGF system. Finally, in order to investigate the regulation of IGF signaling in detail an in vitro system using human immature granulosa cells will be established.

Mulige interessekonflikter

No conflicts of interest.

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