Andrew J Schork

Publikation

Publikationer pr. år 2013 2017 2018 2019 2020 2021 2022 2023 2023

• 30 Tidsskriftartikel
• 1 Konferenceabstrakt til konference
• 1 Kommentar/debat
• 1 Review

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2023

  Accuracy of haplotype estimation and whole genome imputation affects complex trait analyses in complex biobanks

  Appadurai, V., Bybjerg-Grauholm, J., Krebs, M. D., Rosengren, A., Buil, A., Ingason, A., Mors, O., Børglum, A. D., Hougaard, D. M., Nordentoft, M., Mortensen, P. B., Delaneau, O., Werge, T. & Schork, A. J., 26 jan. 2023, I: Communications biology. 6, 1, s. 101 101.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Phasing Method 100%
  • Multifactorial Inheritance 69%
  • Haplotypes 53%
  • Marker 49%
  • haplotypes 48%

• Associations of psychiatric disorders with sex chromosome aneuploidies in the Danish iPSYCH2015 dataset: a case-cohort study

  Sánchez, X. C., Montalbano, S., Vaez, M., Krebs, M. D., Byberg-Grauholm, J., Mortensen, P. B., Børglum, A. D., Hougaard, D. M., Nordentoft, M., Geschwind, D. H., Buil, A., Schork, A. J., Thompson, W. K., Raznahan, A., Helenius, D., Werge, T. & Ingason, A., feb. 2023, I: The Lancet. Psychiatry. 10, 2, s. 129-138 10 s.

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  • Sex Chromosomes 100%
  • Aneuploidy 82%
  • Mental Disorders 62%
  • Datasets 60%
  • Cohort Studies 52%

• Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

  iPSYCH-Broad Consortium, 9 jan. 2023, I: Scientific Reports. 13, 1, s. 429 429.

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  • Creativity 100%
  • Genome-Wide Association Study 80%
  • Psychopathology 76%
  • Language 61%
  • Aptitude 52%

• Interplay of ADHD Polygenic Liability With Birth-Related, Somatic, and Psychosocial Factors in ADHD: A Nationwide Study

  Brikell, I., Wimberley, T., Albiñana, C., Vilhjálmsson, B. J., Agerbo, E., Børglum, A. D., Demontis, D., Schork, A. J., LaBianca, S., Werge, T., Hougaard, D. M., Nordentoft, M., Mors, O., Mortensen, P. B., Petersen, L. V. & Dalsgaard, S., 1 jan. 2023, I: The American journal of psychiatry. 180, 1, s. 73-88 16 s.

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  • Attention Deficit Disorder with Hyperactivity 100%
  • Parturition 68%
  • Psychology 67%
  • Psychiatry 9%
  • Odds Ratio 5%
  2 Citationer (Scopus)

• Polygenic analyses show important differences between MDD symptoms collected using PHQ9 and CIDI-SF

  Huang, L., Tang, S., Rietkerk, J., Appadurai, V., Krebs, M. D., Schork, A. J., Werge, T., Zuber, V., Kendler, K. & Cai, N., 1 mar. 2023, I: medRxiv : the preprint server for health sciences.

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  • Major Depressive Disorder 100%
  • Depression 63%
  • Patient Health Questionnaire 40%
  • Random Allocation 31%
  • Statistical Factor Analysis 28%

• The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

  DBDS Genomic Consortium, mar. 2023, I: Nature Genetics. 55, 3, s. 423-436 14 s.

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  • Endometriosis 100%
  • Comorbidity 74%
  • Pain 54%
  • Migraine Disorders 38%
  • Chronic Pain 34%
• 2022

  Accounting for age of onset and family history improves power in genome-wide association studies

  Pedersen, E. M., Agerbo, E., Plana-Ripoll, O., Grove, J., Dreier, J. W., Musliner, K. L., Bækvad-Hansen, M., Athanasiadis, G., Schork, A., Bybjerg-Grauholm, J., Hougaard, D. M., Werge, T., Nordentoft, M., Mors, O., Dalsgaard, S., Christensen, J., Børglum, A. D., Mortensen, P. B., McGrath, J. J., Privé, F., & 1 flereVilhjálmsson, B. J., 3 mar. 2022, I: American Journal of Human Genetics. 109, 3, s. 417-432 16 s.

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  • Genome-Wide Association Study 100%
  • Age of Onset 90%
  • Psychological Power 90%
  • Age Distribution 63%
  • Research Personnel 26%
  2 Citationer (Scopus)

• A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

  Athanasiadis, G., Meijsen, J. J., Helenius, D., Schork, A. J., Ingason, A., Thompson, W. K., Geschwind, D. H., Werge, T. & Buil, A., 8 feb. 2022, I: Proceedings of the National Academy of Sciences of the United States of America. 119, 6, e2118688119.

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  • Denmark 100%
  • Genetic Profile 61%
  • Demography 60%
  • Delivery of Health Care 57%
  • Social Work 53%

• Cross-trait assortative mating is widespread and inflates genetic correlation estimates

  Border, R., Athanasiadis, G., Buil, A., Schork, A. J., Cai, N., Young, A. I., Werge, T., Flint, J., Kendler, K. S., Sankararaman, S., Dahl, A. W. & Zaitlen, N. A., 18 nov. 2022, I: Science. 378, 6621, s. 754-761 8 s.

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  • Phenotype 100%
  • Mental Disorders 67%
  • Chromosomes 65%
  • Observation 59%
• 2021

  1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

  Sønderby, I. E., van der Meer, D., Moreau, C., Kaufmann, T., Walters, G. B., Ellegaard, M., Abdellaoui, A., Ames, D., Amunts, K., Andersson, M., Armstrong, N. J., Bernard, M., Blackburn, N. B., Blangero, J., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Bülow, R., Bøen, R., Cahn, W., & 31 flereCalhoun, V. D., Caspers, S., Ching, C. R. K., Cichon, S., Ciufolini, S., Crespo-Facorro, B., Curran, J. E., Dale, A. M., Dalvie, S., Dazzan, P., de Geus, E. J. C., de Zubicaray, G. I., de Zwarte, S. M. C., Desrivieres, S., Doherty, J. L., Donohoe, G., Draganski, B., Ehrlich, S., Eising, E., Espeseth, T., Fejgin, K., Fisher, S. E., Fladby, T., Frei, O., Frouin, V., Fukunaga, M., Gareau, T., Jørgensen, N. R., Nielsen, J., Schork, A. J. & ENIGMA-CNV working group, 22 mar. 2021, I: Translational psychiatry. 11, 1, s. 182 1 s., 182.

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  • 1.35-Mb Chromosome 1q21.1 Deletion Syndrome 100%
  • Neurodevelopmental Disorders 59%
  • Brain 50%
  • Trisomy Chromosome 22 42%
  • Cognition 40%
  17 Citationer (Scopus)

• Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors

  Krebs, M. D., Themudo, G. E., Benros, M. E., Mors, O., Børglum, A. D., Hougaard, D., Mortensen, P. B., Nordentoft, M., Gandal, M. J., Fan, C. C., Geschwind, D. H., Schork, A. J., Werge, T. & Thompson, W. K., 16 nov. 2021, I: Nature Communications. 12, 1, 6617.

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  • schizophrenia 100%
  • Heterogeneity 53%
  • Disorder 50%
  • Schizophrenia 47%
  • trajectories 45%

• Genetic, Clinical, and Sociodemographic Factors Associated With Stimulant Treatment Outcomes in ADHD

  Brikell, I., Wimberley, T., Albiñana, C., Pedersen, E. M., Vilhjálmsson, B. J., Agerbo, E., Demontis, D., Børglum, A. D., Schork, A. J., LaBianca, S., Werge, T., Mors, O., Hougaard, D. M., Thapar, A., Mortensen, P. B. & Dalsgaard, S., sep. 2021, I: The American journal of psychiatry. 178, 9, s. 854-864 11 s.

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  • Attention Deficit Disorder with Hyperactivity 100%
  • Genome-Wide Association Study 34%
  • Bipolar Disorder 21%
  • Prescriptions 18%
  • Schizophrenia 17%

• Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders - findings from a Danish population-based study

  Liu, X., Nudel, R., Thompson, W. K., Appadurai, V., Schork, A. J., Buil, A., Rasmussen, S., Allesøe, R. L., Werge, T., Mors, O., Børglum, A. D., Hougaard, D. M., Mortensen, P. B., Nordentoft, M. & Benros, M. E., jan. 2021, I: Brain, Behavior, and Immunity. 91, s. 10-23 14 s.

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  • Autoimmune Diseases 100%
  • Mental Disorders 93%
  • Population 45%
  • Genome-Wide Association Study 27%
  • HLA Antigens 27%
  5 Citationer (Scopus)

• Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status

  Agerbo, E., Trabjerg, B. B., Børglum, A. D., Schork, A. J., Vilhjálmsson, B. J., Pedersen, C. B., Hakulinen, C., Albiñana, C., Hougaard, D. M., Grove, J., McGrath, J. J., Bybjerg-Grauholm, J., Mors, O., Plana-Ripoll, O., Werge, T., Wray, N. R., Mortensen, P. B. & Musliner, K. L., 1 apr. 2021, I: JAMA Psychiatry. 78, 4, s. 387-397 11 s.

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  • Social Class 100%
  • Psychiatry 78%
  • Depression 69%
  • Mental Disorders 19%
  • Psychotic Affective Disorders 16%
• 2020

  A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness

  Nudel, R., Appadurai, V., Schork, A. J., Buil, A., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Mors, O., Hougaard, D. M., Mortensen, P. B., Werge, T., Nordentoft, M., Thompson, W. K. & Benros, M. E., maj 2020, I: Human Genetics. 139, 5, s. 593-604 12 s.

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  • Genetic Predisposition to Disease 100%
  • Infections 46%
  • Population 38%
  • Mental Disorders 31%
  • Single Nucleotide Polymorphism 16%
  11 Citationer (Scopus)

• Association between Mental Disorders and Subsequent Medical Conditions

  Momen, N. C., Plana-Ripoll, O., Agerbo, E., Benros, M. E., Børglum, A. D., Christensen, M. K., Dalsgaard, S., Degenhardt, L., de Jonge, P., Debost, J-C. P. G., Fenger-Grøn, M., Gunn, J. M., Iburg, K. M., Kessing, L. V., Kessler, R. C., Laursen, T. M., Lim, C. C. W., Mors, O., Mortensen, P. B., Musliner, K. L., & 18 flereNordentoft, M., Pedersen, C. B., Petersen, L. V., Ribe, A. R., Roest, A. M., Saha, S., Schork, A. J., Scott, K. M., Sievert, C., Sørensen, H. J., Stedman, T. J., Vestergaard, M., Vilhjalmsson, B., Werge, T., Weye, N., Whiteford, H. A., Prior, A. & McGrath, J. J., 30 apr. 2020, I: The New England journal of medicine. 382, 18, s. 1721-1731 11 s.

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  • Mental Disorders 100%
  • Neurocognitive Disorders 28%
  • Confidence Intervals 12%
  • Population 12%
  • Denmark 10%

• Genetic predictors of educational attainment and intelligence test performance predict voter turnout

  Aarøe, L., Appadurai, V., Hansen, K. M., Schork, A. J., Werge, T., Mors, O., Børglum, A. D., Hougaard, D. M., Nordentoft, M., Mortensen, P. B., Thompson, W. K., Buil, A., Agerbo, E. & Petersen, M. B., 9 nov. 2020, I: Nature Human Behaviour.

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  • Intelligence Tests 100%
  • voter turnout 94%
  • intelligence test 89%
  • performance 35%
  • Multifactorial Inheritance 32%
• 2019

  A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

  Schork, A. J., Won, H., Appadurai, V., Nudel, R., Gandal, M., Delaneau, O., Revsbech Christiansen, M., Hougaard, D. M., Bækved-Hansen, M., Bybjerg-Grauholm, J., Giørtz Pedersen, M., Agerbo, E., Bøcker Pedersen, C., Neale, B. M., Daly, M. J., Wray, N. R., Nordentoft, M., Mors, O., Børglum, A. D., Bo Mortensen, P., & 4 flereBuil, A., Thompson, W. K., Geschwind, D. H. & Werge, T., mar. 2019, I: Nature Neuroscience. 22, 3, s. 353-361 9 s.

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  • Genome-Wide Association Study 100%
  • Mental Disorders 77%
  • Single Nucleotide Polymorphism 53%
  • Psychiatry 47%
  • Genes 38%

• A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population

  Nudel, R., Wang, Y., Appadurai, V., Schork, A. J., Buil, A., Agerbo, E., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Mors, O., Hougaard, D. M., Mortensen, P. B., Werge, T., Nordentoft, M., Thompson, W. K. & Benros, M. E., 11 nov. 2019, I: Translational psychiatry. 9, 1, s. 283 283.

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  • Mental Disorders 100%
  • Infections 58%
  • Population 48%
  • Genome-Wide Association Study 32%
  • Genetic Predisposition to Disease 20%
  35 Citationer (Scopus)

• Exploring Comorbidity Within Mental Disorders Among a Danish National Population

  Plana-Ripoll, O., Pedersen, C. B., Holtz, Y., Benros, M. E., Dalsgaard, S., de Jonge, P., Fan, C. C., Degenhardt, L., Ganna, A., Greve, A. N., Gunn, J., Iburg, K. M., Kessing, L. V., Lee, B. K., Lim, C. C. W., Mors, O., Nordentoft, M., Prior, A., Roest, A. M., Saha, S., & 12 flereSchork, A., Scott, J. G., Scott, K. M., Stedman, T., Sørensen, H. J., Werge, T., Whiteford, H. A., Laursen, T. M., Agerbo, E., Kessler, R. C., Mortensen, P. B. & McGrath, J. J., 1 mar. 2019, I: JAMA Psychiatry. 76, 3, s. 259-270 12 s.

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  • Mental Disorders 100%
  • Comorbidity 96%
  • Population 48%
  • Intellectual Disability 29%
  • Physiological Sexual Dysfunctions 25%
  269 Citationer (Scopus)

• Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap

  CommonMind Consortium, PsychENCODE Consortium, iPSYCH-BROAD Working Group, Steve Horvath, jan. 2019, I: Focus (American Psychiatric Publishing). 17, 1, s. 66-72 7 s.

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  • Neuropathology 100%
  • Mental Disorders 72%

• Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

  Liu, X., Helenius, D., Skotte, L., Beaumont, R. N., Wielscher, M., Geller, F., Juodakis, J., Mahajan, A., Bradfield, J. P., Lin, F. T. J., Vogelezang, S., Bustamante, M., Ahluwalia, T. S., Pitkänen, N., Wang, C. A., Bacelis, J., Borges, M. C., Zhang, G., Bedell, B. A., Rossi, R. M., & 54 flereSkogstrand, K., Peng, S., Thompson, W. K., Appadurai, V., Lawlor, D. A., Kalliala, I., Power, C., McCarthy, M. I., Boyd, H. A., Marazita, M. L., Hakonarson, H., Hayes, M. G., Scholtens, D. M., Rivadeneira, F., Jaddoe, V. W. V., Vinding, R. K., Bisgaard, H., Knight, B. A., Pahkala, K., Raitakari, O., Helgeland, Ø., Johansson, S., Njølstad, P. R., Fadista, J., Schork, A. J., Nudel, R., Miller, D. E., Chen, X., Weirauch, M. T., Mortensen, P. B., Børglum, A. D., Nordentoft, M., Mors, O., Hao, K., Ryckman, K. K., Hougaard, D. M., Kottyan, L. C., Pennell, C. E., Lyytikainen, L-P., Bønnelykke, K., Vrijheid, M., Felix, J. F., Lowe, W. L., Grant, S. F. A., Hyppönen, E., Jacobsson, B., Jarvelin, M-R., Muglia, L. J., Murray, J. C., Freathy, R. M., Werge, T. M., Melbye, M., Buil, A. & Feenstra, B., 2 sep. 2019, I: Nature Communications. 10, 1, s. 3927

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  • genome 100%
  • genes 89%
  • loci 57%
  • Genome 52%
  • Mothers 48%
• 2018

  Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study

  Erlangsen, A., Appadurai, V., Wang, Y., Turecki, G., Mors, O., Werge, T., Mortensen, P. B., Starnawska, A., Børglum, A. D., Schork, A., Nudel, R., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Thompson, W. K., Nordentoft, M. & Agerbo, E., 16 aug. 2018, I: Molecular Psychiatry.

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  • Genome-Wide Association Study 100%
  • Suicide 88%
  • Mental Disorders 77%
  • Single Nucleotide Polymorphism 60%
  • Population 37%
  73 Citationer (Scopus)

• Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

  Gandal, M. J., Haney, J. R., Parikshak, N. N., Leppa, V., Ramaswami, G., Hartl, C., Schork, A. J., Appadurai, V., Buil, A., Werge, T. M., Liu, C., White, K. P., Horvath, S., Geschwind, D. H. & CommonMind Consortium, 9 feb. 2018, I: Science. 359, 6376, s. 693-697 5 s.

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  • Neuropathology 100%
  • Bipolar Disorder 86%
  • Mental Disorders 72%
  • Autistic Disorder 44%
  • Brain 43%
  568 Citationer (Scopus)

• Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia

  Fan, C. C., McGrath, J. J., Appadurai, V., Buil, A., Gandal, M. J., Schork, A. J., Mortensen, P. B., Agerbo, E., Geschwind, S. A., Geschwind, D., Werge, T., Thompson, W. K. & Pedersen, C. B., 13 dec. 2018, I: Nature Communications. 9, 1, s. 5296

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  • schizophrenia 100%
  • environment effects 86%
  • Chromosome Mapping 71%
  • genes 68%
  • Schizophrenia 47%
  12 Citationer (Scopus)
• 2017

  Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry

  Sapkota, Y., Vivo, I. D., Steinthorsdottir, V., Fassbender, A., Bowdler, L., Buring, J. E., Edwards, T. L., Jones, S., O, D., Peterse, D., Rexrode, K. M., Ridker, P. M., Schork, A. J., Thorleifsson, G., Wallace, L. M., Kraft, P., Morris, A. P., Nyholt, D. R., Edwards, D. R. V., Nyegaard, M., & 7 flereD'Hooghe, T., Chasman, D. I., Stefansson, K., Missmer, S. A., Montgomery, G. W., iPSYCH-SSI-Broad Group & Werge, T. M., 12 sep. 2017, I: Scientific Reports. 7, 1, s. 11380

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  • Endometriosis 100%
  • Genome-Wide Association Study 49%
  • Meta-Analysis 35%
  • Proteins 34%
  • Genome 32%
  17 Citationer (Scopus)

• Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases

  Ferrari, R., Wang, Y., Vandrovcova, J., Guelfi, S., Witeolar, A., Karch, C. M., Schork, A. J., Fan, C. C., Brewer, J. B., Momeni, P., Schellenberg, G. D., Dillon, W. P., Sugrue, L. P., Hess, C. P., Yokoyama, J. S., Bonham, L. W., Rabinovici, G. D., Miller, B. L., Andreassen, O. A., Dale, A. M., & 5 flereHardy, J., Desikan, R. S., International FTD-Genomics Consortium (IFGC), Hjermind, L. E. & Nielsen, J. E., feb. 2017, I: Journal of neurology, neurosurgery, and psychiatry. 88, 2, s. 152-164 13 s.

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  • Frontotemporal Dementia 100%
  • Parkinson Disease 67%
  • Alzheimer Disease 62%
  • Genetic Pleiotropy 28%
  • Single Nucleotide Polymorphism 22%
  72 Citationer (Scopus)

• Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

  Sapkota, Y., Steinthorsdottir, V., Morris, A. P., Fassbender, A., Rahmioglu, N., De Vivo, I., Buring, J. E., Zhang, F., Edwards, T. L., Jones, S., O, D., Peterse, D., Rexrode, K. M., Ridker, P. M., Schork, A. J., MacGregor, S., Martin, N. G., Becker, C. M., Adachi, S., Yoshihara, K., & 23 flereEnomoto, T., Takahashi, A., Kamatani, Y., Matsuda, K., Kubo, M., Thorleifsson, G., Geirsson, R. T., Thorsteinsdottir, U., Wallace, L. M., Yang, J., Velez Edwards, D. R., Nyegaard, M., Low, S-K., Zondervan, K. T., Missmer, S. A., D'Hooghe, T., Montgomery, G. W., Chasman, D. I., Stefansson, K., Tung, J. Y., Nyholt, D. R., iPSYCH-SSI-Broad Group & Werge, T. M., 24 maj 2017, I: Nature Communications. 8, s. 15539

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  • hormone metabolisms 100%
  • Gonadal Steroid Hormone 62%
  • hormones 60%
  • genes 50%
  • loci 48%
  184 Citationer (Scopus)
• 2015

  Genetic Markers of Human Evolution Are Enriched in Schizophrenia

  Srinivasan, S., Bettella, F., Mattingsdal, M., Wang, Y., Witoelar, A., Schork, A. J., Thompson, W. K., Zuber, V., Winsvold, B. S., Zwart, J-A., Collier, D. A., Desikan, R. S., Melle, I., Werge, T., Dale, A. M., Djurovic, S., Andreassen, O. A. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, 21 okt. 2015, I: Biological Psychiatry.

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  • Genetic Markers 100%
  • Schizophrenia 77%
  • Neanderthals 70%
  • Proxy 22%
  • Brain 20%
  65 Citationer (Scopus)
• 2013

  Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate

  Andreassen, O. A., Thompson, W. K., Schork, A. J., Ripke, S., Mattingsdal, M., Kelsoe, J. R., Kendler, K. S., O'Donovan, M. C., Rujescu, D., Werge, T., Sklar, P., Roddey, J. C., Chen, C-H., McEvoy, L., Desikan, R. S., Djurovic, S., Dale, A. M. & Psychiatric Genomics Consortium (PGC), apr. 2013, I: P L o S Genetics. 9, 4, s. e1003455

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  • pleiotropy 100%
  • bipolar disorder 99%
  • schizophrenia 83%
  • Bipolar Disorder 58%
  • Schizophrenia 49%
  206 Citationer (Scopus)