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Nefrologisk afdeling - en del af Københavns Universitetshospital
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Organisationsprofil

Aims and objectives

In close collaboration with national and international partners we maintain interest in translational research on mineral homeostasis.Disturbed mineral homeostasis is hallmark of chronic kidney disease (CKD)and important risk factor for morbidity and development of severe cardiovascular complications. We generate translational models to study the pathogenesis and treatment of human kidney diseases and their cardiovascular and skeletal complications. We educate Ph.D. students and physicians in the skills required for biomedical and clinical research.

Focus areas

The focus of research is disordered mineral metabolism across the spectrum of CKD, kidney transplantation and early kidney injury with emphasis on regulation of phosphate, calcium, vitamin D homeostasis by Klotho, fibroblast growth factor 23 and PTH. Emphasis is also put on cardiovascular disease and molecular mechanisms of vascular calcification. 

Disciplines, methods and tools

Experimental models of acute and chronic kidney disease, calcium and phosphate clamping, parathyroidectomy, kidney transplantation, tissue cultures, WB, RT-PCR, RNAseq, ELISA, bone biopsy.

 

Kontaktinformation

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