Ethical and Scientific Considerations Regarding the Early Approval and Deployment of a COVID-19 Vaccine

Dal-Ré, R., Caplan, A. L., Gluud, C. & Porcher, R., 20 nov. 2020, I : Annals of Internal Medicine.

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Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)

Korang, S. K., Juul, S., Nielsen, E. E., Feinberg, J., Siddiqui, F., Ong, G., Klingenberg, S., Veroniki, A. A., Bu, F., Thabane, L., Thomsen, A. R., Jakobsen, J. C. & Gluud, C., 20 nov. 2020, I : Systematic Reviews. 9, 1, s. 262

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Psychotherapy versus treatment as usual and other control interventions in children and adolescents with overweight and obesity: a protocol for systematic review with meta-analysis and Trial Sequential Analysis

Rashid, R., Condon, L., Gluud, C., Jakobsen, J. C., Lindschou, J. & Lissau, I., 5 nov. 2020, I : BMJ Open. 10, 11, s. e036058

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Prophylactic acid suppressants in children in the intensive care unit: a systematic review with meta-analysis and trial sequential analysis

Jensen, M. M., Marker, S., Do, H. Q., Barbateskovic, M., Perner, A. & Møller, M. H., 4 nov. 2020, I : Acta Anaesthesiologica Scandinavica.

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Effect of low vs. high haemoglobin transfusion trigger on cardiac output in patients undergoing elective vascular surgery: post-hoc analysis of a randomised trial

Møller, A., Wetterslev, J., Shahidi, S., Hellemann, D., Secher, N. H., Pedersen, O. B., Marcussen, K. V., Ramsing, B. G. U., Mortensen, A. & Nielsen, H. B., 3 nov. 2020, I : Acta Anaesthesiologica Scandinavica.

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Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan

Jakobsen, J. C., Dankiewicz, J., Lange, T., Cronberg, T., Lilja, G., Levin, H., Bělohlávek, J., Callaway, C., Cariou, A., Erlinge, D., Hovdenes, J., Joannidis, M., Nordberg, P., Oddo, M., Pelosi, P., Kirkegaard, H., Eastwood, G., Rylander, C., Saxena, M., Storm, C., Taccone, F. S., Wise, M. P., Morgan, M. P. G., Young, P., Nichol, A., Friberg, H., Ullén, S. & Nielsen, N., 7 okt. 2020, I : Trials. 21, 1, s. 831

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Loop diuretics in adult intensive care patients with fluid overload: A protocol for a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Wichmann, S., Barbateskovic, M., Lindschou, J., Gluud, C., Perner, A. & Bestle, M. H., 1 okt. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 9, s. 1327-1334

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Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan

Petersen, M. W., Meyhoff, T. S., Helleberg, M., Kjær, M-B. N., Granholm, A., Hjortsø, C. J. S., Jensen, T. S., Møller, M. H., Hjortrup, P. B., Wetterslev, M., Vesterlund, G. K., Russell, L., Jørgensen, V. L., Tjelle, K., Benfield, T., Ulrik, C. S., Andreasen, A. S., Mohr, T., Bestle, M. H., Poulsen, L. M., Hitz, M. F., Hildebrandt, T., Knudsen, L. S., Møller, A., Sølling, C. G., Brøchner, A. C., Rasmussen, B. S., Nielsen, H., Christensen, S., Strøm, T., Cronhjort, M., Wahlin, R. R., Jakob, S., Cioccari, L., Venkatesh, B., Hammond, N., Jha, V., Myatra, S. N., Gluud, C., Lange, T. & Perner, A., 1 okt. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 9, s. 1365-1375 11 s.

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Polycystic ovary syndrome and offspring risk of congenital heart defects: a nationwide cohort study

Schmidt, A. B., Lund, M., Wohlfahrt, J. & Melbye, M., 1 okt. 2020, I : Human reproduction (Oxford, England). 35, 10, s. 2348-2355 8 s.

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The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

Andersen-Ranberg, N., Poulsen, L. M., Perner, A., Wetterslev, J., Mathiesen, O., Mortensen, C. B., Estrup, S., Ebdrup, B. H., Hästbacka, J., Citerio, G., Caballero, J., Morgan, M. P. G., Oxenbøll-Collet, M., Weber, S-O., Andreasen, A. S., Bestle, M. H., Pedersen, H. B. S., Nielsen, L. G., Uslu, B., Jensen, T. B., Thee, C., Dey, N. & Lange, T., 1 okt. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 9, s. 1357-1364 8 s.

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Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Maagaard, M., Nielsen, E. E., Sethi, N. J., Ning, L., Yang, S-H., Gluud, C. & Jakobsen, J. C., okt. 2020, I : Open Heart. 7, 2

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Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

CIMT Trial group, okt. 2020, I : Journal of Diabetes and its Complications. 34, 10, s. 107681 107681.

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Blinding in randomised clinical trials of psychological interventions: a retrospective study of published trial reports

Juul, S., Gluud, C., Simonsen, S., Frandsen, F. W., Kirsch, I. & Jakobsen, J. C., 30 sep. 2020, I : BMJ Evidence-Based Medicine.

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Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial

CIMT study group, 26 sep. 2020, I : Cardiovascular Diabetology. 19, 1, s. 150

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COVID-19 clinical trials: Ethical and scientific consequences of the RECOVERY trial results

Dal-Ré, R., Porcher, R. & Gluud, C., 15 sep. 2020, I : Basic & clinical pharmacology & toxicology.

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Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

Juul, S., Nielsen, E. E., Feinberg, J., Siddiqui, F., Jørgensen, C. K., Barot, E., Nielsen, N., Bentzer, P., Veroniki, A. A., Thabane, L., Bu, F., Klingenberg, S., Gluud, C. & Jakobsen, J. C., sep. 2020, I : PLOS Medicine. 17, 9, s. e1003293

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Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study

Collet, M. O., Egerod, I., Thomsen, T., Wetterslev, J., Lange, T., Ebdrup, B. H. & Perner, A., 27 aug. 2020, I : Acta Anaesthesiologica Scandinavica.

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Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease. A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial

Winkel, P., Jakobsen, J. C., Hilden, J., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Iversen, K. K., Bjerre, M., Larsson, A., Ärnlöv, J. & Gluud, C., 20 aug. 2020, I : BMJ Open. 10, 8, e033720.

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Early head-up mobilisation versus standard care for patients with severe acquired brain injury: A systematic review with meta-analysis and Trial Sequential Analysis

Riberholt, C. G., Wagner, V., Lindschou, J., Gluud, C., Mehlsen, J. & Møller, K., 13 aug. 2020, I : PLoS One. 15, 8, e0237136.

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Was amorphous aluminium hydroxyphosphate sulfate adequately evaluated before authorisation in Europe?

Petersen, S. B. & Gluud, C., 6 aug. 2020, I : BMJ Evidence-Based Medicine.

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Effect of Metformin vs. Placebo in Combination with Insulin Analogues on Bone Markers P1NP and CTX in Patients with Type 2 Diabetes Mellitus

Nordklint, A. K., Almdal, T. P., Vestergaard, P., Lundby-Christensen, L., Jørgensen, N. R., Boesgaard, T. W., Breum, L., Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Krarup, T., Madsbad, S., Mathiesen, E. R., Perrild, H., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Lund, S. S. & Eiken, P., aug. 2020, I : Calcified Tissue International. 107, 2, s. 160-169 10 s.

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Should antidepressants be used for major depressive disorder?

Jakobsen, J. C., Gluud, C. & Kirsch, I., aug. 2020, I : BMJ Evidence-Based Medicine. 25, 4, s. 130-136 7 s.

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The PANSAID Randomized Clinical Trial: A pre-planned 1-year follow-up regarding harm

Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Overgaard, S. & Mathiesen, O., aug. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 7, s. 910-912 3 s.

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Higher vs Lower Oxygenation Strategies in Acutely Ill Adults: A Systematic Review With Meta-Analysis and Trial Sequential Analysis

Barbateskovic, M., Schjørring, O. L., Krauss, S. R., Meyhoff, C. S., Jakobsen, J. J., Rasmussen, B. S., Perner, A. & Wetterslev, J., 17 jul. 2020, I : Chest.

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Dr. Uhre et al. Reply

Uhre, V. F., Uhre, C. F., Lønfeldt, N. N., Pretzmann, L., Vangkilde, S., Plessen, K. J., Gluud, C., Jakobsen, J. C. & Pagsberg, A. K., 1 jul. 2020, I : Journal of the American Academy of Child and Adolescent Psychiatry. 59, 7, s. 787-791 5 s.

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DEX-2-TKA - DEXamethasone twice for pain treatment after Total Knee Arthroplasty. Detailed statistical analysis plan for a randomized, blinded, three-group multicentre clinical trial

Gasbjerg, K. S., Hägi-Pedersen, D., Lunn, T. H., Overgaard, S., Pedersen, N. A., Bagger, J., Lindholm, P., Brorson, S., Schrøder, H. M., Thybo, K. H., Mathiesen, O. & Jakobsen, J. C., jul. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 6, s. 839-846 8 s.

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Prophylactic use of acid suppressants in adult acutely ill hospitalised patients: a systematic review with meta-analysis and trial sequential analysis

Marker, S., Barbateskovic, M., Perner, A., Wetterslev, J., Jakobsen, J. C., Krag, M., Granholm, A., Anthon, C. T. & Møller, M. H., jul. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 6, s. 714-728 15 s.

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Response

Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A. & Wetterslev, J., jul. 2020, I : Chest. 158, 1, s. 428

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The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan

Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Morgan, M., Bäcklund, M., Siegemund, M., Thormar, K. M. & Rasmussen, B. S., jul. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 6, s. 847-856 10 s.

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Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis

Vinkel, J., Holm, N. F. R., Jakobsen, J. C. & Hyldegaard, O., 29 jun. 2020, I : BMJ Open. 10, 6, s. e031708

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Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial

Dutch STRIDER Trial Group, 1 jun. 2020, I : JAMA network open. 3, 6, s. e205323

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Internet-based therapy with FearFighter for anxiety disorders: a randomised clinical trial

Fenger, M., Lindschou, J., Gluud, C., Winkel, P., Jørgensen, L., Dybkjaer, J. H. & Lau, M., 13 maj 2020, I : Nordic Journal of Psychiatry. s. 1-7 7 s.

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Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project)

Juul, S., Nielsen, N., Bentzer, P., Veroniki, A. A., Thabane, L., Linder, A., Klingenberg, S., Gluud, C. & Jakobsen, J. C., 9 maj 2020, I : Systematic Reviews. 9, 1, s. 108

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Long-term mortality in the Intermediate care after emergency abdominal surgery (InCare) trial - a post-hoc follow-up study

Hansted, A. K., Møller, M. H., Møller, A. M., Wetterslev, J., Rosenberg, J., Jorgensen, L. N., Waldau, T. & Vester-Andersen, M., 9 maj 2020, I : Acta Anaesthesiologica Scandinavica.

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Exploratory analyses of the Danish Palliative Care Trial (DanPaCT): a randomized trial of early specialized palliative care plus standard care versus standard care in advanced cancer patients

Johnsen, A. T., Petersen, M. A., Sjøgren, P., Pedersen, L., Neergaard, M. A., Damkier, A., Gluud, C., Fayers, P., Lindschou, J., Strömgren, A. S., Nielsen, J. B., Higginson, I. J. & Groenvold, M., maj 2020, I : Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 28, 5, s. 2145-2155 11 s.

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Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2)

Lilja, G., Nielsen, N., Ullén, S., Nordstrom, E. B., Dankiewicz, J., Friberg, H., Heimburg, K., Jakobsen, J. C., Levin, H., Callaway, C., Cariou, A., Eastwood, G. M., Helbok, R., Hovdenes, J., Kirkegaard, H., Leithner, C., Morgan, M. P. G., Nordberg, P., Oddo, M., Pelosi, P., Rylander, C., Saxena, M., Taccone, F. S., Siranec, M., Wise, M. P., Young, P. J. & Cronberg, T., maj 2020, I : Resuscitation. 150, s. 104-112 9 s.

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Self-determination theory interventions versus usual care in people with diabetes: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis. Under review.

Mathiesen, A. S., Rothmann, M., Zoffmann, V., Jakobsen, J. C., Gluud, C., Lindschou, J., Due-Christensen, M., Rasmussen, B., H.S. Marqvordsen, E. & Thomsen, T., maj 2020, I : Prospero.

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Serum osteoprotegerin as a long-term predictor for patients with stable coronary artery disease and its association with diabetes and statin treatment: A CLARICOR trial 10-year follow-up substudy

Bjerre, M., Hilden, J., Winkel, P., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Larsson, A., Ärnlöv, J., Jakobsen, J. C. & Gluud, C., maj 2020, I : Atherosclerosis. 301, s. 8-14 7 s.

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Methylphenidate for ADHD rejected from the WHO Essential Medicines List due to uncertainties in benefit-harm profile

Storebø, O. J. & Gluud, C., 24 apr. 2020, I : BMJ Evidence-Based Medicine.

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Eversion technique versus conventional endarterectomy with patch angioplasty in carotid surgery: protocol for a systematic review with meta-analyses and trial sequential analysis of randomised clinical trials

Marsman, M. S., Wetterslev, J., Vriens, P. W. H. E., Bleys, R. L. A. W., Jahrome, A. K., Moll, F. L., Keus, F. & Koning, G. G., 19 apr. 2020, I : BMJ Open. 10, 4, s. e030503

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Arterial oxygen tensions in mechanically ventilated ICU patients and mortality: a retrospective, multicentre, observational cohort study

Schjørring, O. L., Jensen, A. K. G., Nielsen, C. G., Ciubotariu, A., Perner, A., Wetterslev, J., Lange, T. & Rasmussen, B. S., apr. 2020, I : British Journal of Anaesthesia. 124, 4, s. 420-429 10 s.

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Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A. & Møller, M. H., apr. 2020, I : Intensive Care Medicine. 46, 4, s. 717-726 10 s.

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Letter to the Editor: Glucocorticosteroids for Alcohol-Associated Hepatitis

Varganova, D. L., Pavlov, C. S., Casazza, G., Nikolova, D. & Gluud, C., apr. 2020, I : Hepatology (Baltimore, Md.). 71, 4, s. 1524

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Early specialised palliative care: interventions, symptoms, problems

Skjoedt, N., Johnsen, A. T., Sjøgren, P., Neergaard, M. A., Damkier, A., Gluud, C., Lindschou, J., Fayers, P., Higginson, I. J., Strömgren, A. S. & Groenvold, M., 27 mar. 2020, I : BMJ Supportive and Palliative Care.

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Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

Schroder, J., Jakobsen, J. C., Winkel, P., Hilden, J., Jensen, G. B., Sajadieh, A., Larsson, A., Ärnlöv, J., Harutyunyan, M., Johansen, J. S., Kjøller, E., Gluud, C. & Kastrup, J., 3 mar. 2020, I : Journal of the American Heart Association. 9, 5, s. e014634

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Hyperoxia and antioxidants during major non-cardiac surgery and risk of cardiovascular events: Protocol for a 2 × 2 factorial randomised clinical trial

Petersen, C., Loft, F. C., Aasvang, E. K., Vester-Andersen, M., Rasmussen, L. S., Wetterslev, J., Jorgensen, L. N., Christensen, R. & Meyhoff, C. S., mar. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 3, s. 400-409 10 s.

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Health apps targeting children with overweight-a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials

Rashid, R., Perego, P., Condon, L., Jakobsen, J. C., Lindschou, J., Gluud, C., Andreoni, G. & Lissau, I., 11 feb. 2020, I : Systematic Reviews. 9, 1, 28.

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Haloperidol for the treatment of delirium in critically ill patients: a systematic review with meta-analysis and Trial Sequential Analysis

Barbateskovic, M., Krauss, S. R., Collet, M. O., Andersen-Ranberg, N. C., Mathiesen, O., Jakobsen, J. C., Perner, A. & Wetterslev, J., feb. 2020, I : Acta Anaesthesiologica Scandinavica. 64, 2, s. 254-266 13 s.

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Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how

Nørskov, A. K., Lange, T., Nielsen, E. E., Gluud, C., Winkel, P., Beyersmann, J., de Uña-Álvarez, J., Torri, V., Billot, L., Putter, H., Wetterslev, J., Thabane, L. & Jakobsen, J. C., 27 jan. 2020, I : BMJ Evidence-Based Medicine.

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Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

Volf, C., Aggestrup, A. S., Petersen, P. M., Dam-Hansen, C., Knorr, U., Petersen, E. E., Engstrøm, J., Jakobsen, J. C., Hansen, T. S., Madsen, H. Ø., Hageman, I. & Martiny, K., 26 jan. 2020, I : BMJ Open. 10, 1, s. e032233

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