Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

HOT-ICU Investigators, Bertelsen Jensen, D., Mørk Sørensen, K., Sprogøe Rasmussen, P., Rovsing Hjortdal, A., Reiter, N., Clausen, N. E., Hein, L., Ibsen, M. & Sigurðsson, S. Þ., 8 apr. 2021, I: The New England journal of medicine. 384, 14, s. 1301-1311 11 s.

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Lenient rate control versus strict rate control for atrial fibrillation: a protocol for the Danish Atrial Fibrillation (DanAF) randomised clinical trial

Feinberg, J. B., Olsen, M. H., Brandes, A., Raymond, L., Nielsen, W. B., Nielsen, E. E., Stensgaard-Hansen, F., Dixen, U., Pedersen, O. D., Gang, U. J. O., Gluud, C. & Jakobsen, J. C., 31 mar. 2021, I: BMJ Open. 11, 3, s. 1-9 9 s., e044744.

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Effect of low vs. high haemoglobin transfusion trigger on cardiac output in patients undergoing elective vascular surgery: Post-hoc analysis of a randomized trial

Møller, A., Wetterslev, J., Shahidi, S., Hellemann, D., Secher, N. H., Pedersen, O. B., Marcussen, K. V., Ramsing, B. G. U., Mortensen, A. & Nielsen, H. B., mar. 2021, I: Acta Anaesthesiologica Scandinavica. 65, 3, s. 302-312 11 s.

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Prophylactic acid suppressants in children in the intensive care unit: a systematic review with meta-analysis and trial sequential analysis

Jensen, M. M., Marker, S., Do, H. Q., Barbateskovic, M., Perner, A. & Møller, M. H., mar. 2021, I: Acta Anaesthesiologica Scandinavica. 65, 3, s. 292-301 10 s.

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Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial

Nordklint, A. K., Almdal, T. P., Vestergaard, P., Lundby-Christensen, L., Boesgaard, T. W., Breum, L., Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Perrild, H., Madsbad, S., Mathiesen, E. R., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Lund, S. S. & Eiken, P., 16 feb. 2021, (E-pub ahead of print) I: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.

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Higher vs. Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: protocol for a secondary Bayesian analysis

Granholm, A., Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Kjaer, M-B. N., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Møller, M. H., Benfield, T., Venkatesh, B., Hammond, N., Micallef, S., Bassi, A., John, O., Jha, V., Tjelle Kristiansen, K., Ulrik, C. S., Jørgensen, V. L., Smitt, M., Bestle, M. H., Andreasen, A. S., Poulsen, L. M., Rasmussen, B. S., Brøchner, A. C., Strøm, T., Møller, A., Khan, M. S., Padmanaban, A., Vasishtha Divatia, J., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Gluud, C., Lange, T. & Perner, A., 14 feb. 2021, (E-pub ahead of print) I: Acta Anaesthesiologica Scandinavica.

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Higher vs. Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: protocol and statistical analysis plan

Munch, M. W., Granholm, A., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Kjaer, M-B. N., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Møller, M. H., Benfield, T., Venkatesh, B., Hammond, N., Micallef, S., Bassi, A., John, O., Jha, V., Tjelle Kristiansen, K., Ulrik, C. S., Jørgensen, V. L., Smitt, M., Bestle, M. H., Andreasen, A. S., Poulsen, L. M., Rasmussen, B. S., Brøchner, A. C., Strøm, T., Møller, A., Khan, M. S., Padmanaban, A., Divatia, J. V., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Gluud, C., Lange, T. & Perner, A., 14 feb. 2021, (E-pub ahead of print) I: Acta Anaesthesiologica Scandinavica.

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A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

Barbateskovic, M., Koster, T. M., Eck, R. J., Maagaard, M., Afshari, A., Blokzijl, F., Cronhjort, M., Dieperink, W., Fabritius, M. L., Feinberg, J., French, C., Gareb, B., Geisler, A., Granholm, A., Hiemstra, B., Hu, R., Imberger, G., Jensen, B. T., Jonsson, A. B., Karam, O., Kong, D. Z., Korang, S. K., Koster, G., Lai, B., Liang, N., Lundstrøm, L. H., Marker, S., Meyhoff, T., Nielsen, E. E., Nørskov, A. K., Munch, M. W., Risom, E. C., Rygård, S. L., Safi, S., Sethi, N., Sjövall, F., Lauridsen, S. V., van Bakelen, N., Volbeda, M., van der Horst, I., Gluud, C., Perner, A., Møller, M. H., Keus, F. & Wetterslev, J., 6 feb. 2021, (E-pub ahead of print) I: Journal of Clinical Epidemiology. 135, s. 29-41 13 s.

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An internet-based emotion regulation intervention versus no intervention for nonsuicidal self-injury in adolescents: study protocol for a feasibility trial

Morthorst, B., Rubæk, L., Lindschou, J., Jakobsen, J. C., Gluud, C., Bjureberg, J., Hellner, C., Møhl, B. & Pagsberg, A. K., 6 feb. 2021, I: Pilot and Feasibility Studies. 7, 1, s. 44

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Ethical and Scientific Considerations Regarding the Early Approval and Deployment of a COVID-19 Vaccine

Dal-Ré, R., Caplan, A. L., Gluud, C. & Porcher, R., 1 feb. 2021, I: Annals of Internal Medicine. 174, 2, s. 258-260 3 s.

Publikation: Bidrag til tidsskrift › Leder › peer review

Functional muscle synergies to support the knee against moment specific loads while weight bearing

Flaxman, T. E., Shourijeh, M. S., Smale, K. B., Alkjær, T., Simonsen, E. B., Krogsgaard, M. R. & Benoit, D. L., feb. 2021, I: Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. 56, s. 102506

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Self-determination theory interventions versus usual care in people with diabetes: a protocol for a systematic review with meta-analysis and trial sequential analysis

Mathiesen, A. S., Rothmann, M. J., Zoffmann, V., Jakobsen, J. C., Gluud, C., Lindschou, J., Due-Christensen, M., Rasmussen, B., Marqvorsen, E. & Thomsen, T., 7 jan. 2021, I: Systematic Reviews. 10, 1, s. 12

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Higher vs Lower Oxygenation Strategies in Acutely Ill Adults: A Systematic Review With Meta-Analysis and Trial Sequential Analysis

Barbateskovic, M., Schjørring, O. L., Krauss, S. R., Meyhoff, C. S., Jakobsen, J. J., Rasmussen, B. S., Perner, A. & Wetterslev, J., jan. 2021, I: Chest. 159, 1, s. 154-173 20 s.

Publikation: Bidrag til tidsskrift › Review › peer review

Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study

Collet, M. O., Egerod, I., Thomsen, T., Wetterslev, J., Lange, T., Ebdrup, B. H. & Perner, A., jan. 2021, I: Acta Anaesthesiologica Scandinavica. 65, 1, s. 92-99 8 s.

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Antibiotic regimens for early‐onset neonatal sepsis (Protocol)

Korang, S. K., Safi, S., Gupta, M., Gordon, A., Greisen, G., Lausten-Thomsen, U. & Jakobsen, J. C., 2021, I: Cochrane Database of Systematic Reviews. s. CD013837

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Antibiotic regimens for late‐onset neonatal sepsis (Protocol)

Korang, S. K., Safi, S., Gupta, M., Greisen, G., Lausten-Thomsen, U. & Jakobsen, J. C., 2021, I: Cochrane Database of Systematic Reviews. s. CD013836

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Antibiotics for hospital‐acquired pneumonia in neonates and children (Protocol)

Korang, S. K., Nava, C., Nygaard, U. & Jakobsen, J. C., 2021, I: Cochrane Database of Systematic Reviews. s. CD013864

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Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how

Nørskov, A. K., Lange, T., Nielsen, E. E., Gluud, C., Winkel, P., Beyersmann, J., de Uña-Álvarez, J., Torri, V., Billot, L., Putter, H., Wetterslev, J., Thabane, L. & Jakobsen, J. C., 2021, (E-pub ahead of print) I: BMJ Evidence-Based Medicine.

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Blinding in randomised clinical trials of psychological interventions: a retrospective study of published trial reports

Juul, S., Gluud, C., Simonsen, S., Frandsen, F. W., Kirsch, I. & Jakobsen, J. C., 2021, (E-pub ahead of print) I: BMJ Evidence-Based Medicine.

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Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation

Gurusamy, K. S., Moher, D., Loizidou, M., Ahmed, I., Avey, M. T., Barron, C. C., Davidson, B., Dwek, M., Gluud, C., Jell, G., Katakam, K., Montroy, J., McHugh, T. D., Osborne, N. J., Ritskes-Hoitinga, M., van Laarhoven, K., Vollert, J. & Lalu, M., 2021, I: PeerJ. 9, s. e10673

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Considerations on the strengths and limitations of using disease-related mortality as an outcome in clinical research

Jakobsen, J. C., Wetterslev, J. & Gluud, C., 2021, (E-pub ahead of print) I: BMJ Evidence-Based Medicine.

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review

Early specialised palliative care: interventions, symptoms, problems

Skjoedt, N., Johnsen, A. T., Sjøgren, P., Neergaard, M. A., Damkier, A., Gluud, C., Lindschou, J., Fayers, P., Higginson, I. J., Strömgren, A. S. & Groenvold, M., 2021, (E-pub ahead of print) I: BMJ Supportive and Palliative Care.

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Methylphenidate for ADHD rejected from the WHO Essential Medicines List due to uncertainties in benefit-harm profile

Storebø, O. J. & Gluud, C., 2021, (E-pub ahead of print) I: BMJ Evidence-Based Medicine.

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Was amorphous aluminium hydroxyphosphate sulfate adequately evaluated before authorisation in Europe?

Petersen, S. B. & Gluud, C., 2021, (E-pub ahead of print) I: BMJ Evidence-Based Medicine.

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Comparison of different mobile health applications for intervention in children and adolescent with overweight: a protocol for systematic review with meta-analysis and trial sequential analysis

Perego, P., Rashid, R., Gluud, C., Jakobsen, J. C., Andreoni, G. & Lissau, I., 7 dec. 2020, I: BMJ Open. 10, 12, s. e032570 032570.

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COVID-19 clinical trials: Ethical and scientific consequences of the RECOVERY trial results

Dal-Ré, R., Porcher, R. & Gluud, C., dec. 2020, I: Basic & clinical pharmacology & toxicology. 127, 6, s. 445-447 3 s.

Publikation: Bidrag til tidsskrift › Letter › peer review

Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention

Claire, R., Gluud, C., Berlin, I., Coleman, T. & Leonardi-Bee, J., 30 nov. 2020, I: BMC Medical Research Methodology. 20, 1, s. 284

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Prompt closure versus gradual weaning of external ventricular drainage for hydrocephalus in adult patients with aneurysmal subarachnoid haemorrhage: a systematic review

Capion, T., Lilja-Cyron, A., Juhler, M., Mathiesen, T. I. & Wetterslev, J., 26 nov. 2020, I: BMJ Open. 10, 11, s. e040722

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Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)

Korang, S. K., Juul, S., Nielsen, E. E., Feinberg, J., Siddiqui, F., Ong, G., Klingenberg, S., Veroniki, A. A., Bu, F., Thabane, L., Thomsen, A. R., Jakobsen, J. C. & Gluud, C., 20 nov. 2020, I: Systematic Reviews. 9, 1, s. 262

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Psychotherapy versus treatment as usual and other control interventions in children and adolescents with overweight and obesity: a protocol for systematic review with meta-analysis and Trial Sequential Analysis

Rashid, R., Condon, L., Gluud, C., Jakobsen, J. C., Lindschou, J. & Lissau, I., 5 nov. 2020, I: BMJ Open. 10, 11, s. e036058

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Beneficial and harmful effects of sacubitril/valsartan in patients with heart failure: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Nielsen, E. E., Feinberg, J. B., Bu, F-L., Hecht Olsen, M., Raymond, I., Steensgaard-Hansen, F. & Jakobsen, J. C., nov. 2020, I: Open Heart. 7, 2

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Seeing is believing – the problem of blinding in psychological research

Juul, S., Gluud, C., Simonsen, S., Weicher Frandsen, F., Kirsch, I. & Jakobsen, J. C., 7 okt. 2020, I: Evidence-Based Medicine.

Publikation: Bidrag til tidsskrift › Letter

Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan

Jakobsen, J. C., Dankiewicz, J., Lange, T., Cronberg, T., Lilja, G., Levin, H., Bělohlávek, J., Callaway, C., Cariou, A., Erlinge, D., Hovdenes, J., Joannidis, M., Nordberg, P., Oddo, M., Pelosi, P., Kirkegaard, H., Eastwood, G., Rylander, C., Saxena, M., Storm, C., Taccone, F. S., Wise, M. P., Morgan, M. P. G., Young, P., Nichol, A., Friberg, H., Ullén, S. & Nielsen, N., 7 okt. 2020, I: Trials. 21, 1, s. 831 831.

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Loop diuretics in adult intensive care patients with fluid overload: A protocol for a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Wichmann, S., Barbateskovic, M., Lindschou, J., Gluud, C., Perner, A. & Bestle, M. H., 1 okt. 2020, I: Acta Anaesthesiologica Scandinavica. 64, 9, s. 1327-1334 8 s.

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Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan

Petersen, M. W., Meyhoff, T. S., Helleberg, M., Kjær, M-B. N., Granholm, A., Hjortsø, C. J. S., Jensen, T. S., Møller, M. H., Hjortrup, P. B., Wetterslev, M., Vesterlund, G. K., Russell, L., Jørgensen, V. L., Tjelle, K., Benfield, T., Ulrik, C. S., Andreasen, A. S., Mohr, T., Bestle, M. H., Poulsen, L. M., Hitz, M. F., Hildebrandt, T., Knudsen, L. S., Møller, A., Sølling, C. G., Brøchner, A. C., Rasmussen, B. S., Nielsen, H., Christensen, S., Strøm, T., Cronhjort, M., Wahlin, R. R., Jakob, S., Cioccari, L., Venkatesh, B., Hammond, N., Jha, V., Myatra, S. N., Gluud, C., Lange, T. & Perner, A., 1 okt. 2020, I: Acta Anaesthesiologica Scandinavica. 64, 9, s. 1365-1375 11 s.

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The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

Andersen-Ranberg, N., Poulsen, L. M., Perner, A., Wetterslev, J., Mathiesen, O., Mortensen, C. B., Estrup, S., Ebdrup, B. H., Hästbacka, J., Citerio, G., Caballero, J., Morgan, M. P. G., Oxenbøll-Collet, M., Weber, S-O., Andreasen, A. S., Bestle, M. H., Pedersen, H. B. S., Nielsen, L. G., Uslu, B., Jensen, T. B., Thee, C., Dey, N. & Lange, T., 1 okt. 2020, I: Acta Anaesthesiologica Scandinavica. 64, 9, s. 1357-1364 8 s.

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Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Maagaard, M., Nielsen, E. E., Sethi, N. J., Ning, L., Yang, S-H., Gluud, C. & Jakobsen, J. C., okt. 2020, I: Open Heart. 7, 2, 001288.

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Internet-based therapy with FearFighter for anxiety disorders: a randomised clinical trial

Fenger, M., Lindschou, J., Gluud, C., Winkel, P., Jørgensen, L., Dybkjaer, J. H. & Lau, M., okt. 2020, I: Nordic Journal of Psychiatry. 74, 7, s. 518-524 7 s.

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Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

Winckler, K., Thorsteinsson, B., Wiinberg, N., Jensen, A. K., Lundby-Christensen, L., Heitmann, B. L., Lund, S. S., Krarup, T., Jensen, T., Vestergaard, H., Breum, L., Sneppen, S., Boesgaard, T., Madsbad, S., Gluud, C., Vaag, A., Almdal, T. P., Tarnow, L. & CIMT Trial group, okt. 2020, I: Journal of Diabetes and its Complications. 34, 10, s. 107681 107681.

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Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial

Hansen, C. S., Lundby-Christiansen, L., Tarnow, L., Gluud, C., Hedetoft, C., Thorsteinsson, B., Hemmingsen, B., Wiinberg, N., Sneppen, S. B., Lund, S. S., Krarup, T., Madsbad, S., Almdal, T., Carstensen, B., Jørgensen, M. E. & CIMT study group, 26 sep. 2020, I: Cardiovascular Diabetology. 19, 1, s. 150 150.

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Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

Juul, S., Nielsen, E. E., Feinberg, J., Siddiqui, F., Jørgensen, C. K., Barot, E., Nielsen, N., Bentzer, P., Veroniki, A. A., Thabane, L., Bu, F., Klingenberg, S., Gluud, C. & Jakobsen, J. C., sep. 2020, I: PLOS Medicine. 17, 9, s. e1003293

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Long-term mortality in the Intermediate care after emergency abdominal surgery (InCare) trial - a post-hoc follow-up study

Hansted, A. K., Møller, M. H., Møller, A. M., Wetterslev, J., Rosenberg, J., Jorgensen, L. N., Waldau, T. & Vester-Andersen, M., sep. 2020, I: Acta Anaesthesiologica Scandinavica. 64, 8, s. 1100-1105 6 s.

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Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease. A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial

Winkel, P., Jakobsen, J. C., Hilden, J., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Iversen, K. K., Bjerre, M., Larsson, A., Ärnlöv, J. & Gluud, C., 20 aug. 2020, I: BMJ Open. 10, 8, e033720.

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Early head-up mobilisation versus standard care for patients with severe acquired brain injury: A systematic review with meta-analysis and Trial Sequential Analysis

Riberholt, C. G., Wagner, V., Lindschou, J., Gluud, C., Mehlsen, J. & Møller, K., 13 aug. 2020, I: PLoS One. 15, 8, e0237136.

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Effect of Metformin vs. Placebo in Combination with Insulin Analogues on Bone Markers P1NP and CTX in Patients with Type 2 Diabetes Mellitus

Nordklint, A. K., Almdal, T. P., Vestergaard, P., Lundby-Christensen, L., Jørgensen, N. R., Boesgaard, T. W., Breum, L., Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Krarup, T., Madsbad, S., Mathiesen, E. R., Perrild, H., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Lund, S. S. & Eiken, P., aug. 2020, I: Calcified Tissue International. 107, 2, s. 160-169 10 s.

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Should antidepressants be used for major depressive disorder?

Jakobsen, J. C., Gluud, C. & Kirsch, I., aug. 2020, I: BMJ Evidence-Based Medicine. 25, 4, s. 130-136 7 s.

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The PANSAID Randomized Clinical Trial: A pre-planned 1-year follow-up regarding harm

Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Overgaard, S. & Mathiesen, O., aug. 2020, I: Acta Anaesthesiologica Scandinavica. 64, 7, s. 910-912 3 s.

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Dr. Uhre et al. Reply

Uhre, V. F., Uhre, C. F., Lønfeldt, N. N., Pretzmann, L., Vangkilde, S., Plessen, K. J., Gluud, C., Jakobsen, J. C. & Pagsberg, A. K., 1 jul. 2020, I: Journal of the American Academy of Child and Adolescent Psychiatry. 59, 7, s. 787-791 5 s.

Publikation: Bidrag til tidsskrift › Letter › peer review

DEX-2-TKA - DEXamethasone twice for pain treatment after Total Knee Arthroplasty. Detailed statistical analysis plan for a randomized, blinded, three-group multicentre clinical trial

Gasbjerg, K. S., Hägi-Pedersen, D., Lunn, T. H., Overgaard, S., Pedersen, N. A., Bagger, J., Lindholm, P., Brorson, S., Schrøder, H. M., Thybo, K. H., Mathiesen, O. & Jakobsen, J. C., jul. 2020, I: Acta Anaesthesiologica Scandinavica. 64, 6, s. 839-846 8 s.

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Prophylactic use of acid suppressants in adult acutely ill hospitalised patients: a systematic review with meta-analysis and trial sequential analysis

Marker, S., Barbateskovic, M., Perner, A., Wetterslev, J., Jakobsen, J. C., Krag, M., Granholm, A., Anthon, C. T. & Møller, M. H., jul. 2020, I: Acta Anaesthesiologica Scandinavica. 64, 6, s. 714-728 15 s.

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