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Region Hovedstaden - en del af Københavns Universitetshospital

Effect of electroconvulsive therapy on cortical thickness in patients with depression – a longitudinal MRI study

Aktivitet: Tale eller præsentationForedrag og mundtlige bidrag

Dokumenter

  1. Det Danske ECT/MRI projekt

    Projekt: Typer af projekter

  1. Cortical thickness following electroconvulsive therapy in patients with depression - a longitudinal MRI study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Electroconvulsive therapy increases cortical thickness in depression

    Publikation: KonferencebidragPosterForskning

  3. Electroconvulsive therapy increases cortical thickness in depression

    Publikation: KonferencebidragPosterForskning

  1. National Klinisk Retningslinje vedr. vanskelig behandlelig depression

    Aktivitet: AndetAndet (priser, ekstern undervisning samt andet). - Andet

  2. Ugerskrift for Læger (Tidsskrift)

    Aktivitet: Publikation af peer-review og redaktionelt arbejdeRedaktør af tidsskriftForskning

  3. DPS Årsmøde

    Aktivitet: Deltagelse i eller arrangering af en begivenhedOrganisation af og deltagelse i konference

  4. Psykiatrifonden (Ekstern organisation)

    Aktivitet: MedlemsskabMedlemskab af styrelse i virksomhed eller organisation

  5. Retslægerådet (Ekstern organisation)

    Aktivitet: MedlemsskabMedlemskab af udvalg, råd og nævn

  6. Rådet for Dyr Sygehusmedicin (RADS) (Ekstern organisation)

    Aktivitet: MedlemsskabMedlemskab af udvalg, råd og nævn

  7. Dansk Depressions Database (Danske Regioner) (Ekstern organisation)

    Aktivitet: MedlemsskabMedlemskab af udvalg, råd og nævn

  8. Dansk Psykiatrisk Selskab (Ekstern organisation)

    Aktivitet: MedlemsskabMedlemskab af styrelse i virksomhed eller organisation

Krzysztof Gbyl - Foredragsholder

Poul Videbech - Foredragsholder

Martin Balslev Jørgensen - Foredragsholder

Egill Rostrup - Foredragsholder

Lejla Sjanic Schmidt - Foredragsholder

Jayachandra Mitta Raghava - Foredragsholder

Jonathan Frederik Carlsen - Foredragsholder

A Ashraf - Foredragsholder

Henrik Bo Wiberg Larsson - Foredragsholder

Raben Rosenberg - Foredragsholder

Ulrich Lindberg - Foredragsholder

Aim:
Several studies have found an increase in hippocampal volume following a series of electroconvulsive therapy (ECT), but the effect on cortical thickness has been less investigated. We aimed to examine the short- and long-term effect of ECT on changes in cortical thickness and their associations with clinical outcome.

Methods:
Using 3 Tesla MRI-scanner, we obtained T1-weighted brain images of 18 severely depressed patients at three time points: befor, right after, and six months after a series of ECT. The thickness of 68 cortical regions was extracted using Free Surfer, and Linear Mixed Model was used to analyse the longitudinal changes.

Results:
We found significant increases in cortical thickness of 26 regions right after the series of ECT, mainly within the frontal, temporal and insular cortex. The thickness returned to the baseline-values at six-month follow-up. No significant decreases in cortical thickness were detected. The increase in thickness of the right lateral orbitofrontal cortex was correlated to at greater antidepressant effect, r-0.75, p-0.0005. None of the regions showed any associations with cognitive side effects.

Conclusion:
The findings support the neurotrophic hypothesis of ECT's mechanism of action and do not support the notion that ECT has a harmful effect on the cortex.
19 jun. 2019

Begivenhed (Konference)

TitelRHPs Forskningsdag 2019
Dato19/06/201919/06/2019
AfholdelsesstedRigshopsitalet, Aud. 1
ByKøbenhavn
LandDanmark

ID: 57684648