Krzysztof Gbyl - Foredragsholder
Poul Videbech - Foredragsholder
Martin Balslev Jørgensen - Foredragsholder
Egill Rostrup - Foredragsholder
Lejla Sjanic Schmidt - Foredragsholder
Jayachandra Mitta Raghava - Foredragsholder
Jonathan Frederik Carlsen - Foredragsholder
A Ashraf - Foredragsholder
Henrik Bo Wiberg Larsson - Foredragsholder
Raben Rosenberg - Foredragsholder
Ulrich Lindberg - Foredragsholder
Aim:
Several studies have found an increase in hippocampal volume following a series of electroconvulsive therapy (ECT), but the effect on cortical thickness has been less investigated. We aimed to examine the short- and long-term effect of ECT on changes in cortical thickness and their associations with clinical outcome.
Methods:
Using 3 Tesla MRI-scanner, we obtained T1-weighted brain images of 18 severely depressed patients at three time points: befor, right after, and six months after a series of ECT. The thickness of 68 cortical regions was extracted using Free Surfer, and Linear Mixed Model was used to analyse the longitudinal changes.
Results:
We found significant increases in cortical thickness of 26 regions right after the series of ECT, mainly within the frontal, temporal and insular cortex. The thickness returned to the baseline-values at six-month follow-up. No significant decreases in cortical thickness were detected. The increase in thickness of the right lateral orbitofrontal cortex was correlated to at greater antidepressant effect, r-0.75, p-0.0005. None of the regions showed any associations with cognitive side effects.
Conclusion:
The findings support the neurotrophic hypothesis of ECT's mechanism of action and do not support the notion that ECT has a harmful effect on the cortex.
19 jun. 2019
Titel | RHPs Forskningsdag 2019 |
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Dato | 19/06/2019 → 19/06/2019 |
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Afholdelsessted | Rigshopsitalet, Aud. 1 |
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By | København |
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Land | Danmark |
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