Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Zinc Oxide Inhibits Axillary Colonization by Members of the Genus Corynebacterium and Attenuates Self-perceived Malodour: A Randomized, Double-blind, Placebo-controlled Trial

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Incidence of Kaposi Sarcoma in Sweden is Decreasing

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Staphylococcus aureus Augments Release of Matrix Metalloproteinase-8 from Human Polymorpho-nuclear Leukocytes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Skin Microbiome in Atopic Dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Antibiotics during childhood and development of appendicitis-a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incisional hernia repair in women of childbearing age: A nationwide propensity-score matched study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Malodour from the axilla is commonly caused by specific microbes, and may be inhibited by zinc oxide. The aim of this study was to determine the effects of zinc oxide on the axillary microbiota, odour and pH in a randomized, double-blind, placebo-controlled trial in 30 healthy volunteers. In each participant one axilla was treated with zinc oxide and the other with a placebo for 13 days. The microbiota and pH were analysed before and during treatment. At the final visit, the participants judged their own axillary odour for comparison. With zinc oxide treatment total bacterial growth and, specifically, that of odour-producing Co-rynebacterium spp. and Staphylococcus hominis, decreased (p < 0.05), despite an increase (p < 0.0005) in skin-surface pH. Compared with the placebo, zinc oxide treatment reduced (p = 0.005) self-perceived malodour. In vitro, Corynebacterium spp. (19 isolated strains) survival was reduced (p < 0.0005) at pH 5.0 compared with pH 6.0; growth inhibition by zinc oxide occurred at ≤ 400 mg/l, and cell death occurred at ≤ 10,000 mg/l for 12 (63%) of the strains. In conclusion, application of zinc oxide reduced malodour and the counts of causative bacteria, but increased the pH of the axilla.

Original languageEnglish
Article numberadv00145
JournalActa Dermato-Venereologica
Volume100
Issue number10
Pages (from-to)1-6
Number of pages6
ISSN0001-5555
DOIs
Publication statusPublished - 28 May 2020

    Research areas

  • Malodour, Microbiota, Skin pH, Susceptibility tests, Topical antiseptics

ID: 61104171