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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Verapamil is Less Effective than Triamcinolone for Prevention of Keloid Scar Recurrence After Excision in a Randomized Controlled Trial

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  • Patricia L Danielsen
  • Suzanne M Rea
  • Fiona M Wood
  • Mark W Fear
  • Helena M Viola
  • Livia C Hool
  • Thilanee U Gankande
  • Mansour Alghamdi
  • Andrew W Stevenson
  • Mitali Manzur
  • Hilary J Wallace
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A double-blind randomized controlled trial with a paired split-scar design compared verapamil, an L-type Ca2+ channel antagonist, and triamcinolone for prevention of keloid recurrence after excision. Ca2+ channel blocking activity of verapamil in keloid cells was explored. One keloid was excised per subject and each wound half randomized to receive intralesional injections of triamcinolone (10 mg/ml) or verapamil (2.5 mg/ml) at monthly intervals (4 doses). Interim analysis was performed after 14 subjects were completed. Survival analysis demonstrated significantly higher keloid recurrence with verapamil compared to triamcinolone 12 months post-surgery (log-rank test, p = 0.01) and higher overall risk of recurrence with verapamil (hazard ratio 8.44, 95% CI 1.62-44.05). The study was terminated early according to the stopping guideline (p < 0.05). Verapamil is safe but not as effective as triamcinolone in preventing keloid recurrence after excision. Further study is necessary to determine if clinical response to verapamil is linked to modulation of intracellular Ca2+.

Original languageEnglish
JournalActa Dermato-Venereologica
Volume96
Issue number6
Pages (from-to)774-8
Number of pages5
ISSN0001-5555
DOIs
Publication statusPublished - 23 Aug 2016

    Research areas

  • Adolescent, Adult, Cicatrix, Double-Blind Method, Female, Glucocorticoids, Humans, Injections, Intralesional, Keloid, Male, Middle Aged, Recurrence, Treatment Outcome, Triamcinolone Acetonide, Vasodilator Agents, Verapamil, Journal Article, Randomized Controlled Trial

ID: 49763351