Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Timing and topography of cerebral blood flow, aura, and headache during migraine attacks

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Melanopsin retinal ganglion cell loss in Alzheimer's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The acute brain response to levodopa heralds dyskinesias in Parkinson disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 25-Hydroxyvitamin D and symptomatic ischemic stroke: An Original Study and Meta-Analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Regulation of regional cerebral blood flow during and between migraine attacks

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Ten years of study has resulted in considerable but fragmented knowledge about regional cerebral blood flow in migraine with aura (classic migraine). In the present study, the number of repeatedly studied patients (n = 63) was large enough to determine statistically significant sequences of events and statistically significant spatial relations. The first observable event was a decrease of regional cerebral blood flow posteriorly in one cerebral hemisphere. Further development of this pathological process was accompanied by the aura symptoms. Thereafter headache occurred while regional cerebral blood flow remained decreased. During the headache phase, regional cerebral blood flow gradually changed from abnormally low to abnormally high without apparent change in headache. In some patients headache disappeared while regional cerebral blood flow remained increased. Although regional cerebral blood flow reduction and aura symptoms in the great majority of patients were unilateral, one-third had bilateral headache. Unilateral headache usually localized to the side on which regional cerebral blood flow was reduced and from which the aura symptoms originated (i.e., aura symptoms were perceived to occur contralaterally but presumably originated in the hypoperfused hemisphere). Our results suggest a simple model for migraine attacks: A pathological disturbance in one cerebral hemisphere causes the aura symptoms and after a time delay, it also causes the headache by stimulating local vascular nociceptors. Bilateral headache caused by a unilateral cerebral disturbance may be explained by recent neuroanatomical and neurophysiological findings.
Original languageEnglish
JournalAnnals of Neurology
Volume28
Issue number6
Pages (from-to)791-8
Number of pages8
ISSN0364-5134
DOIs
Publication statusPublished - Dec 1990

Bibliographical note

Timing and topography of cerebral blood flow, aura, and headache during migraine attacks

Jes Olesen MD1, Lars Friberg MD3, Dr Tom Skyhøj Olsen MD1,*, Helle K. Iversen MD1, Niels A. Lassen MD3, Allan R. Andersen MD2 andAgnete Karle MD4
Article first published online: 8 OCT 2004

DOI: 10.1002/ana.410280610

Copyright © 1990 American Neurological Association
Issue Annals of Neurology
Annals of Neurology
Volume 28, Issue 6, pages 791–798, December 1990

Additional Information(Show All)
How to CiteAuthor InformationPublication History

Author Information
1Department of Neurology, Gentofte Hospital, Denmark
2Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark
3Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
4Department of Radiology, Bispebjerg Hospital, Copenhagen, Denmark
*Department of Neurology, Gentofte Hospital, University of Copenhagen, 2900-Copenhagen,

    Research areas

  • Adolescent, Adult, Aged, Brain Mapping, Cerebral Angiography, Cerebral Cortex, Cerebrovascular Circulation, Female, Functional Laterality, Humans, Male, Middle Aged, Migraine Disorders, Time Factors, Tomography, Emission-Computed, Single-Photon

ID: 39047752