Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Muscle-strain injury exudate favors acute tissue healing and prolonged connective tissue formation in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Carbon-14 bomb pulse dating shows that tendinopathy is preceded by years of abnormally high collagen turnover

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Trine S Nicolaisen
  • Anders B Klein
  • Oksana Dmytriyeva
  • Jens Lund
  • Lars Roed Ingerslev
  • Andreas Mæchel Fritzen
  • Christian Strini Carl
  • Anne-Marie Lundsgaard
  • Mikkel Frost
  • Tao Ma
  • Peter Schjerling
  • Zachary Philip Gerhart-Hines
  • Frederic Flamant
  • Katrine Gauthier
  • Steen Larsen
  • Erik A Richter
  • Bente Kiens
  • Christoffer Clemmensen
View graph of relations
Thyroid hormones are important for homeostatic control of energy metabolism and body temperature. Although skeletal muscle is considered a key site for thyroid action, the contribution of thyroid hormone receptor signaling in muscle to whole-body energy metabolism and body temperature has not been resolved. Here, we show that T3-induced increase in energy expenditure requires thyroid hormone receptor alpha 1 (TRα1 ) in skeletal muscle, but that T3-mediated elevation in body temperature is achieved in the absence of muscle-TRα1 . In slow-twitch soleus muscle, loss-of-function of TRα1 (TRαHSACre ) alters the fiber-type composition toward a more oxidative phenotype. The change in fiber-type composition, however, does not influence the running capacity or motivation to run. RNA-sequencing of soleus muscle from WT mice and TRαHSACre mice revealed differentiated transcriptional regulation of genes associated with muscle thermogenesis, such as sarcolipin and UCP3, providing molecular clues pertaining to the mechanistic underpinnings of TRα1 -linked control of whole-body metabolic rate. Together, this work establishes a fundamental role for skeletal muscle in T3-stimulated increase in whole-body energy expenditure.
Original languageEnglish
JournalFASEB Journal
ISSN0892-6638
Publication statusPublished - Nov 2020

ID: 61777602