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Bispebjerg Hospital - a part of Copenhagen University Hospital
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The transcriptome of hand eczema assessed by tape stripping

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Guidelines for diagnosis, prevention, and treatment of hand eczema

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence rates of occupational contact dermatitis in Denmark between 2007 and 2018 - A population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. New evidence on the minimal important change (MIC) for the Hand Eczema Severity Index (HECSI)

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Assessment of biomarkers in pediatric atopic dermatitis by tape strips and skin biopsies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Guidelines for diagnosis, prevention, and treatment of hand eczema

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Factors associated with ocular surface disease and severity in adults with atopic dermatitis: a nationwide survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. No association between omalizumab use and risk of cancer: a nationwide registry-based cohort study

    Research output: Contribution to journalLetterResearchpeer-review

  • Julie B K Sølberg
  • Anna S Quaade
  • Stine B Jacobsen
  • Jeppe D Andersen
  • Marie-Louise Kampmann
  • Niels Morling
  • Thomas Litman
  • Jacob P Thyssen
  • Jeanne D Johansen
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BACKGROUND: No biomarkers have been identified that can classify subtypes of hand eczema (HE). Although skin biopsies represent the gold standard for investigations of the skin, the invasive technique is not favorable when investigating skin from sensitive areas. Recent advances in the use of skin-tape strips for molecular investigations enable noninvasive investigations of HE.

OBJECTIVE: By using whole transcriptome sequencing (WTS), the molecular profile of HE according to different localizations on the hands, etiologies, and clinical/morphological subtypes was investigated.

METHODS: Thirty adult, Danish HE patients, 12 with and 18 without concurrent atopic dermatitis (AD), as well as 16 controls were included. Tape strip samples were collected from lesional, nonlesional, and healthy skin. Total RNA was extracted and WTS was performed.

RESULTS: The largest molecular difference of HE patients with and without AD was found in nonlesional skin areas and included a downregulation of CXCL8 for HE patients without AD. Differences between allergic and irritant contact dermatitis included epidermal biomarkers such as EPHA1.

CONCLUSION: Skin tape strip samples could be used to assess the gene expression profile of HE on different localizations of the hands. The skin tape strip method identified new molecular markers that showed promising result for the identification of HE subtypes.

Original languageEnglish
JournalContact Dermatitis
Volume86
Issue number2
Pages (from-to)71-79
Number of pages9
ISSN0105-1873
DOIs
Publication statusPublished - Feb 2022

Bibliographical note

© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 72505784