Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

The Incidence and Disease Course of Perianal Crohn's Disease: A Danish Nationwide Cohort Study, 1997-2015

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The Pathogenesis of Extraintestinal Manifestations: Implications for IBD research, diagnosis and therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cardiovascular risk profile among patients with inflammatory bowel disease: A population-based study of >100,000 individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ikke alt er hæmorroider. Om diagnostik og behandling af akutte anallidelser i almen praksis.

    Research output: Contribution to journalJournal articleCommunication

  2. Behandling af analabscesser

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease: A Population-Based Danish Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Anastomotic leak after surgery for colon cancer and effect on long-term survival

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background and Aims: Perianal Crohn's disease [CD] places a considerable burden on patients' quality of life and is complex to treat. Despite its impact and high frequency, few studies have investigated the incidence and disease course of perianal CD. The aim of this study was to assess the incidence and disease course of perianal CD in adult patients throughout a 19-year period. Methods: The cohort comprised all individuals aged 18 years or older who were diagnosed with CD in Denmark between January 1, 1997, and December 31, 2015, according to the National Patient Registry [NPR]. Results: A total of 1812 [19%] out of 9739 patients with CD were found to have perianal CD. Perianal fistulas were the most common manifestation, accounting for 943 [52%] cases. The incidence of perianal CD remained stable over time. Patients with perianal CD were found to have an increased risk of undergoing major abdominal surgery compared with patients without perianal CD (hazard ratio: 1.51, 95% confidence interval [CI]: 1.40 to 1.64, p <0.001) in a multivariate Cox regression analysis. The incidence rate ratios of anal and rectal cancer in perianal CD patients were 11.45 [95% CI: 4.70 to 27.91, p <0.001] and 2.29 [95% CI: 1.25 to 4.20, p = 0.006], respectively, as compared with non-IBD matched controls. Conclusions: In this nationwide study, 19% of CD patients developed perianal disease. Patients with perianal CD were at increased risk of undergoing major surgery compared with non-perianal CD patients. The risk of anal and rectal cancer was increased in patients with perianal CD compared with non-IBD matched controls. Podcast: This article has an associated podcast which can be accessed at https://academic.oup.com/ecco-jcc/pages/podcast

Original languageEnglish
JournalJournal of Crohn's & colitis
Volume15
Issue number1
Pages (from-to)5-13
Number of pages9
ISSN1873-9946
DOIs
Publication statusPublished - 13 Jan 2021

    Research areas

  • Crohn's disease, Perianal disease, rectal and anal cancer

ID: 60187818