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Bispebjerg Hospital - a part of Copenhagen University Hospital
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The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population: the copenhagen city heart study

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  1. Kidney function and the prognostic value of myocardial performance index

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  2. The prognostic value of left atrial dyssynchrony measured by speckle tracking echocardiography in the general population

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  3. Association between regional longitudinal strain and left ventricular thrombus formation following acute myocardial infarction

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  4. Evaluation of computed tomography myocardial perfusion in women with angina and no obstructive coronary artery disease

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  1. Chronic productive cough and inhalant occupational exposure-a study of the general population

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  2. Corticosteroid Resistance in Smokers-A Substudy Analysis of the CORTICO-COP Randomised Controlled Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Kidney function and the prognostic value of myocardial performance index

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The prognostic value of left atrial dyssynchrony measured by speckle tracking echocardiography in the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

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Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present prospective longitudinal study included 689 participants of the 4th and 5th Copenhagen City Heart Study who had GLS measured at both timepoints. Mean age was 51 years and 45% were male. All participants underwent two echocardiographic examinations median 10.4 (IQR: 10.2, 10.9) years apart. Average decline in GLS during follow-up was -0.7%. High age, male sex, high body mass index, and mean arterial blood pressure (MAP) proved to be significantly associated with an accelerated decline in GLS. In a multivariable regression model including all the investigated cardiovascular risk factors, age (stand. β-coef. = -0.10, P = 0.005), male sex (stand. β-coef. = -0.16, P < 0.001), and MAP (stand. β-coef. = -0.07, P = 0.009) were independent predictors of an accelerated decline in GLS during a 10-year period. Finally, the investigated risk factors had different regional impact after the same multivariable adjustments. Male sex had a significant impact on changes in longitudinal strain at the apical, mid-wall and basal segments, meanwhile MAP and age only accelerated changes in the mid-wall and basal longitudinal strain. In the general population age, male sex, and MAP are independent predictors of an accelerated decline in GLS over a 10-year period. Furthermore, MAP, male sex and age had different regional impact.

Original languageEnglish
JournalThe international journal of cardiovascular imaging
Volume36
Issue number10
Pages (from-to)1907-1916
Number of pages10
ISSN1569-5794
DOIs
Publication statusPublished - Oct 2020

    Research areas

  • Adaptation, Physiological, Adult, Aged, Cardiovascular Diseases/diagnostic imaging, Denmark/epidemiology, Echocardiography, Doppler, Female, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, Ventricular Function, Left, Ventricular Remodeling, Echocardiography, General population, Global longitudinal strain, Risk factors

ID: 61265868