Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

The effect of remote ischaemic preconditioning on endothelial function after hip fracture surgery

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Programmed, intermittent boluses versus continuous infusion to the sciatic nerve - a non-inferiority randomized, controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Continuing professional development (CPD) for anesthesiologists: a systematic review protocol

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. COVID-19 versus influenza A/B supeRInfectionS in the IntenSive care unit (CRISIS): Protocol for a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Phrenic Nerve Block on Severe Post-Hepatectomy Shoulder Pain: A Randomized, Double-blind, Placebo-controlled, Pilot Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Variable oxygen administration in surgical and medical wards evaluated by 30-day mortality - an observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Timing of surgical site infection and pulmonary complications after laparotomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Sarah Ekeloef
  • Ossian Gundel
  • Andreas Falkenberg
  • Ole Mathiesen
  • Ismail Gögenur
View graph of relations

BACKGROUND: Endothelial dysfunction seems to play a role in the pathophysiology of myocardial injury after surgery. The aim of this randomised clinical trial was to examine whether remote ischaemic preconditioning in relation to hip fracture surgery ameliorates post-operative systemic endothelial dysfunction.

METHODS: This was a planned single-centre pilot sub-study of a multicentre, randomised clinical trial. Patients ≥45 years with a cardiovascular risk factor were randomised to remote ischaemic preconditioning (RIPC) or control (standard treatment) performed in relation with their hip fracture operation. RIPC consisted of four cycles of 5 minutes forearm ischaemia and reperfusion. The procedure was performed non-invasively with a tourniquet. The endothelial function was assessed with non-invasive digital pulse amplitude tonometry on post-operative day 1 and expressed as the reactive hyperaemia index (RHI). Endothelial dysfunction was defined as RHI < 1.22.

RESULTS: Between February 2015 and December 2016, 18 patients were allocated to the RIPC group and 20 patients to the control group. The endothelial function was impaired in both groups on post-operative day 1. RHI did not differ between the groups, 1.47 (95% CI 1.20-1.75) in the RIPC group vs. 1.54 (95% CI 1.17-1.91) in the control group, P = .76. Endothelial dysfunction was present in 3/18 patients (16.7%) in the RIPC group and 8/20 patients (40%) in the control group, P = .11.

CONCLUSION: No beneficial effect of remote ischaemic preconditioning on the systemic endothelial dysfunction, assessed at a single time point on post-operative day one, was detected after hip fracture surgery.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume65
Issue number2
Pages (from-to)169-175
Number of pages7
ISSN0001-5172
DOIs
Publication statusPublished - Feb 2021

    Research areas

  • endothelium, perioperative medicine, preconditioning

ID: 62355987