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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Systematic Assessment of Difficult-to-Treat Asthma: Principles and Perspectives

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  1. The Prevalence of Subtypes of Type 2 Inflammation in an Unselected Population of Patients with Severe Asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Desloratadine Use During Pregnancy and Risk of Adverse Fetal Outcomes: A Nationwide Cohort Study

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  3. IgE-Mediated Multimorbidities in Allergic Asthma and the Potential for Omalizumab Therapy

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  4. Development of the International Severe Asthma Registry (ISAR): a modified Delphi study

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  5. Reply to Crépeaux et al and Blasco

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  1. The Prevalence of Subtypes of Type 2 Inflammation in an Unselected Population of Patients with Severe Asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics

    Research output: Contribution to journalReviewpeer-review

  3. The Danish severe asthma register: an electronic platform for severe asthma management and research

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Physiological abnormalities in patients admitted with acute exacerbation of COPD: an observational study with continuous monitoring

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  5. International severe asthma registry (ISAR): protocol for a global registry

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  • Mark Hew
  • Andrew Menzies-Gow
  • James H Hull
  • Louise Fleming
  • Celeste Porsbjerg
  • Anneke Ten Brinke
  • David Allen
  • Robin Gore
  • Tunn Ren Tay
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Difficult-to-treat asthma affects a minority of adults and children with asthma but represents a challenging mix of misdiagnosis, multimorbidity, inadequate self-management, severe airway pathobiology, and treatment complications. Management of these patients extends beyond asthma pharmacotherapy, because multiple other patient-related domains need to be addressed as well. Such complexity can hinder adequate clinical assessment even when performed in specialist practice. Systematic assessment undertaken by specialized multidisciplinary teams brings a broad range of resources to bear on patients with difficult-to-treat asthma. Although the concept of systematic assessment is not new, practices vary considerably and implementation is not universal. Nevertheless, assessment protocols are already in place in several institutions worldwide, and outcomes after such assessments have been highly encouraging. This review discusses the rationale, components, and benefits of systematic assessment, outlining its clinical utility and the available evidence for improved outcomes. It describes a range of service configurations and assessment approaches, drawing examples from severe asthma centers around the world to highlight common essential elements. It also provides a framework for establishing such services and discusses practical considerations for implementation.

Original languageEnglish
JournalThe journal of allergy and clinical immunology. In practice
Volume8
Issue number7
Pages (from-to)2222-2233
Number of pages12
ISSN2213-2198
DOIs
Publication statusPublished - 8 Aug 2020

    Research areas

  • Adherence, Comorbidities, Diagnosis, Difficult asthma, Personalized medicine, Protocolized, Severe asthma, Treatable traits

ID: 60518442