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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Skin Microbiome in Atopic Dermatitis

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DOI

  1. Incidence of Kaposi Sarcoma in Sweden is Decreasing

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

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  3. Staphylococcus aureus Augments Release of Matrix Metalloproteinase-8 from Human Polymorpho-nuclear Leukocytes

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  1. Håndeksem og vådt arbejde

    Research output: Contribution to journalReviewpeer-review

  2. Cytokine concentration across the stratum corneum in atopic dermatitis and healthy controls

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  3. Comparing DADA2 and OTU clustering approaches in studying the bacterial communities of atopic dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

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Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus. In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.

Original languageEnglish
JournalActa Dermato-Venereologica
Volume100
Issue number12
Pages (from-to)adv00164
ISSN0001-5555
DOIs
Publication statusPublished - 9 Jun 2020

ID: 61746522