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Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity

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Larsen, SC, Ängquist, L, Moldovan, M, Huikari, V, Sebert, S, Cavadino, A, Singh Ahluwalia, T, Skaaby, T, Linneberg, A, Husemoen, LLN, Toft, U, Pedersen, O, Hansen, T, Herzig, K-H, Jarvelin, M-R, Power, C, Hyppönen, E, Heitmann, BL & Sørensen, TIA 2016, 'Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity', P L o S One, vol. 11, no. 4, pp. e0153611. https://doi.org/10.1371/journal.pone.0153611

APA

Larsen, S. C., Ängquist, L., Moldovan, M., Huikari, V., Sebert, S., Cavadino, A., Singh Ahluwalia, T., Skaaby, T., Linneberg, A., Husemoen, L. L. N., Toft, U., Pedersen, O., Hansen, T., Herzig, K-H., Jarvelin, M-R., Power, C., Hyppönen, E., Heitmann, B. L., & Sørensen, T. I. A. (2016). Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity. P L o S One, 11(4), e0153611. https://doi.org/10.1371/journal.pone.0153611

CBE

MLA

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Author

Larsen, Sofus C ; Ängquist, Lars ; Moldovan, Max ; Huikari, Ville ; Sebert, Sylvain ; Cavadino, Alana ; Singh Ahluwalia, Tarunveer ; Skaaby, Tea ; Linneberg, Allan ; Husemoen, Lise Lotte N ; Toft, Ulla ; Pedersen, Oluf ; Hansen, Torben ; Herzig, Karl-Heinz ; Jarvelin, Marjo-Riitta ; Power, Chris ; Hyppönen, Elina ; Heitmann, Berit L ; Sørensen, Thorkild I A. / Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference : Influence of Genetic Predisposition to Adiposity. In: P L o S One. 2016 ; Vol. 11, No. 4. pp. e0153611.

Bibtex

@article{2cdbb1a8b16148db9556c3db94e80c57,
title = "Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity",
abstract = "Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.",
author = "Larsen, {Sofus C} and Lars {\"A}ngquist and Max Moldovan and Ville Huikari and Sylvain Sebert and Alana Cavadino and {Singh Ahluwalia}, Tarunveer and Tea Skaaby and Allan Linneberg and Husemoen, {Lise Lotte N} and Ulla Toft and Oluf Pedersen and Torben Hansen and Karl-Heinz Herzig and Marjo-Riitta Jarvelin and Chris Power and Elina Hypp{\"o}nen and Heitmann, {Berit L} and S{\o}rensen, {Thorkild I A}",
year = "2016",
doi = "10.1371/journal.pone.0153611",
language = "English",
volume = "11",
pages = "e0153611",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference

T2 - Influence of Genetic Predisposition to Adiposity

AU - Larsen, Sofus C

AU - Ängquist, Lars

AU - Moldovan, Max

AU - Huikari, Ville

AU - Sebert, Sylvain

AU - Cavadino, Alana

AU - Singh Ahluwalia, Tarunveer

AU - Skaaby, Tea

AU - Linneberg, Allan

AU - Husemoen, Lise Lotte N

AU - Toft, Ulla

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Herzig, Karl-Heinz

AU - Jarvelin, Marjo-Riitta

AU - Power, Chris

AU - Hyppönen, Elina

AU - Heitmann, Berit L

AU - Sørensen, Thorkild I A

PY - 2016

Y1 - 2016

N2 - Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.

AB - Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.

U2 - 10.1371/journal.pone.0153611

DO - 10.1371/journal.pone.0153611

M3 - Journal article

C2 - 27077659

VL - 11

SP - e0153611

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 4

ER -

ID: 46418507