Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Corrigendum to "Large Incisional Hernias Increase in Size" [Journal of Surgical Research 2019; 244: 160-165.]

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. The Cost Implications of Dabigatran in Patients with Myocardial Injury After Non-Cardiac Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Dangers of hyperoxia

    Research output: Contribution to journalReviewResearchpeer-review

  4. Letter the editor: serious methodological concerns about a recently published meta-analysis on oxygen therapy

    Research output: Contribution to journalLetterResearchpeer-review

  5. Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Original languageEnglish
JournalAnaesthesia
Volume77
Issue number1
Pages (from-to)28-39
Number of pages12
ISSN0003-2409
DOIs
Publication statusPublished - Jan 2022

    Research areas

  • COVID-19, deep vein thrombosis, pulmonary embolism, SARS-CoV-2, venous thromboembolism

ID: 67450473