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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Prolonged binding of radiolabeled recombinant tissue-type plasminogen activator after angioplasty and enclosed thrombolysis of the femoropopliteal arteries

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The authors measured the binding of indium-111-labeled recombinant tissue-type plasminogen activator (rt-PA) within the recanalized femoropopliteal segment after percutaneous transluminal angioplasty (PTA) and enclosed thrombolysis. In patients with long occlusions (n = 3), 91 micrograms of rt-PA was bound 1 hour after the procedure, and the half-time of the final washout curve averaged 114 hours. After PTA in patients with multiple stenoses (n = 6), 45 micrograms of rt-PA was bound, and the half-time averaged 32 hours. These values were significantly smaller than those in patients with occlusions (P <.01). In patients with a single stenosis (n = 4), 19 micrograms of rt-PA was bound, and the half-time averaged 5 hours. These values were significantly smaller than those in patients with multiple stenoses (P <.01). The progressive accumulation of rt-PA at the sites of PTA therapy is most likely related to increasing presence of fibrin with increasing lesion severity. Fibrin accumulation may be partly responsible for early failures after PTA in extensive lesions. Removal of this fibrin with enclosed thrombolysis might improve patency.
Original languageEnglish
JournalJournal of Vascular and Interventional Radiology
Volume3
Issue number4
Pages (from-to)627-32
Number of pages6
ISSN1051-0443
Publication statusPublished - Nov 1992

    Research areas

  • Aged, Angioplasty, Balloon, Arterial Occlusive Diseases, Female, Femoral Artery, Humans, Indium Radioisotopes, Male, Popliteal Artery, Recombinant Proteins, Thrombolytic Therapy, Time Factors, Tissue Plasminogen Activator

ID: 39049565