Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Pretreatment with 5-Fluorouracil Cream Enhances the Efficacy of Daylight-mediated Photodynamic Therapy for Actinic Keratosis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A novel LC-MS/MS method to quantify eumelanin and pheomelanin and their relation to UVR sensitivity - A study on human skin biopsies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Daylight photodynamic therapy of actinic keratosis without curettage is as effective as with curettage: a randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Daylight PDT acts by continuous activation of PpIX

    Research output: Contribution to journalEditorialResearchpeer-review

  5. Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone. At 3-month follow-up the overall lesion response rate was significantly higher for the combination of 5-FU and daylight-PDT (62.7%) than for daylight-PDT alone (51.8%) (p = 0.001). Furthermore, pain and erythema in relation to treatment were similar in the 2 groups (p = 1.0 and p = 0.2, respectively). Combination therapy is a safe and effective method to improve daylight-PDT for acral AKs.

Original languageEnglish
JournalActa Dermato-Venereologica
Volume97
Issue number5
Pages (from-to)617-621
Number of pages5
ISSN0001-5555
DOIs
Publication statusPublished - 8 May 2017

    Research areas

  • Journal Article

ID: 52376727