Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital

Power and color Doppler ultrasound settings for inflammatory flow: impact on scoring of disease activity in patients with rheumatoid arthritis

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Outcome domains reported in calcium pyrophosphate deposition studies: A scoping review by the OMERACT CPPD working group

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To determine how settings for power and color Doppler ultrasound sensitivity vary on different high- and intermediate-range ultrasound machines and to evaluate the impact of these changes on Doppler scoring of inflamed joints.

METHODS: Six different types of ultrasound machines were used. On each machine, the factory setting for superficial musculoskeletal scanning was used unchanged for both color and power Doppler modalities. The settings were then adjusted for increased Doppler sensitivity, and these settings were designated study settings. Eleven patients with rheumatoid arthritis (RA) with wrist involvement were scanned on the 6 machines, each with 4 settings, generating 264 Doppler images for scoring and color quantification. Doppler sensitivity was measured with a quantitative assessment of Doppler activity: color fraction. Higher color fraction indicated higher sensitivity.

RESULTS: Power Doppler was more sensitive on half of the machines, whereas color Doppler was more sensitive on the other half, using both factory settings and study settings. There was an average increase in Doppler sensitivity, despite modality, of 78% when study settings were applied. Over the 6 machines, 2 Doppler modalities, and 2 settings, the grades for each of 7 of the patients varied between 0 and 3, while the grades for each of the other 4 patients varied between 0 and 2.

CONCLUSION: The effect of using different machines, Doppler modalities, and settings has a considerable influence on the quantification of inflammation by ultrasound in RA patients, and this must be taken into account in multicenter studies.

Original languageEnglish
JournalArthritis and Rheumatology
Issue number2
Pages (from-to)386-95
Number of pages10
Publication statusPublished - Feb 2015

Bibliographical note


    Research areas

  • Arthritis, Rheumatoid, Humans, Inflammation, Musculoskeletal System, Sensitivity and Specificity, Severity of Illness Index, Ultrasonography, Doppler, Color, Wrist Joint

ID: 46264070