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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Pediatric toxic epidermal necrolysis treated successfully with infliximab

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

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  • Lana Chafranska
  • Ditte Marie Saunte
  • Nille Behrendt
  • Ulrikka Nygaard
  • Ryan J Christensen
  • Carsten Sand
  • Gregor B Jemec
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Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.

Original languageEnglish
JournalPediatric Dermatology
Volume36
Issue number3
Pages (from-to)342-345
Number of pages4
ISSN0736-8046
DOIs
Publication statusPublished - May 2019

    Research areas

  • Child, Dermatologic Agents/therapeutic use, Humans, Infliximab/therapeutic use, Male, Mycoplasma pneumoniae/isolation & purification, Stevens-Johnson Syndrome/drug therapy

ID: 58959023