Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Patient reported exposure to smoking and alcohol abuse are associated with pain and other complications in patients with chronic pancreatitis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Evaluation of local instillation of antibiotics in infected walled-off pancreatic necrosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Contrast enhanced ultrasonography in acute pancreatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Endoskopisk ultralyd-vejledt etablering af transmurale anastomoser i øvre gastrointestinalkanal.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis: A multicentre study of 1117 cases

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Scandinavian Baltic Pancreatic Club
View graph of relations

BACKGROUND/OBJECTIVES: Smoking and alcohol abuse are established risk factors for chronic pancreatitis (CP). Few studies have examined how exposure to smoking and alcohol abuse act as risk factors for complications in CP. Our aim was to examine associations between patient reported exposure to smoking and alcohol abuse and complications in CP in a large cohort of patients from the Scandinavian and Baltic countries.

METHODS: We retrieved data on demographics, CP related complications and patients' histories of exposure to smoking and alcohol abuse from the Scandinavian Baltic Pancreatic Club database. Associations were investigated by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals.

RESULTS: A complete history of smoking and alcohol exposure was available for 932 patients. In multivariate regression analyses, the presence of pain and exocrine pancreatic insufficiency were both significantly associated with history of smoking (OR 1.94 (1.40-2.68), p < 0.001 and OR 1.89 (1.36-2.62), p < 0.001, respectively) and alcohol abuse (OR 1.66 (1.21-2.26), p = 0.001 and 1.55 (1.14-2.11), p = 0.005, respectively). Smoking was associated with calcifications (OR 2.89 (2.09-3.96), p < 0.001), moderate to severe ductal changes (OR 1.42 (1.05-1.92), p = 0.02), and underweight (OR 4.73 (2.23-10.02), p < 0.001). History of alcohol abuse was associated with pseudocysts (OR 1.38 (1.00-1.90) p = 0.05) and diabetes mellitus (OR 1.44 (1.03-2.01), p = 0.03). There were significantly increased odds-ratios for several complications with increasing exposure to smoking and alcohol abuse.

CONCLUSION: Smoking and alcohol abuse are both independently associated with development of complications in patients with CP. There seems to be a dose-dependent relationship between smoking and alcohol abuse and complications in CP.

Original languageEnglish
JournalPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Volume20
Issue number5
Pages (from-to)844-851
Number of pages8
ISSN1424-3903
DOIs
Publication statusPublished - 1 Jul 2020

    Research areas

  • Alcohol abuse, Chronic pancreatitis, Complications, Epidemiology, Smoking

ID: 60014222