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Bispebjerg Hospital - a part of Copenhagen University Hospital

Muscles adaptation to aging and training: architectural changes - a randomised trial

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  1. Mechanical properties of human patellar tendon collagen fibrils. An exploratory study of aging and sex

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Different training responses in elderly men and women following a prolonged muscle resistance training intervention

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mechanical properties and UTE-T2* in Patellar tendinopathy: The effect of load magnitude in exercise-based treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Altered Triceps Surae Muscle-Tendon Unit Properties after 6 Months of Static Stretching

    Research output: Contribution to journalJournal articleResearchpeer-review

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BACKGROUND: To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo.

METHODS: The old participants were randomly assigned to moderate (O55, n = 13) or high-load (O80, n = 14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n = 11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans.

RESULTS: Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+ 96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+ 4.3%; + 6.7%; 4.2% respectively) and triceps surae (+ 2.8%; + 7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed.

CONCLUSIONS: Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass.

TRIAL REGISTRATION: NCT03079180 in . Registration date: March 14, 2017.

Original languageEnglish
Article number48
JournalBMC Geriatrics
Issue number1
Pages (from-to)48
Publication statusPublished - 13 Jan 2021

    Research areas

  • Ageing, Anatomical cross-sectional area, Muscle volume, Non-contractile tissue, Resistance training

ID: 61811029