Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Local recurrence rate in a national Danish patient cohort after curative treatment for rectal cancer

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Severity and 1-month outcome of SARS-CoV-2 infection in patients with solid cancers: a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Adverse health behaviours in long-term testicular cancer survivors: a Danish nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Incidence of surgical interventions for metastatic bone disease in the extremities: a population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Tomografía computarizada para el diagnóstico de la apendicitis aguda en adultos

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Computed tomography for diagnosis of acute appendicitis in adults

    Research output: Contribution to journalReviewResearchpeer-review

  3. The COLOFOL trial: study design and comparison of the study population with the source cancer population

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: Several trials have shown that preoperative (chemo)radiotherapy (CRT) reduces local recurrence rates (LRRs) in rectal cancer (RC). The use of CRT varies greatly between countries. It is unknown whether the restrictive use of CRT in Denmark results in a higher LRR relative to other countries. The aim was to evaluate the LRR in a national Danish consecutive cohort of patients with RC.

METHODS: All data from patients with RC in Denmark in 2009-2010 who were operated on with curative intent were retrieved from the Danish Colorectal Cancer Group database. Patients with metastases at the time of diagnosis, patients with synchronous colon cancer, and patients, in whom only local surgical procedures were performed, were excluded. In total, 1633 patients met the inclusion criteria. Clinical follow-up was at least five years with a cut-off date of 31 December 2015.

RESULTS: Clinical follow-up was 5.4 years (median) with an interquartile range of 4.5-6.1 years. Of all included patients, 479 (29%) were treated with preoperative long-course CRT. Local recurrence was found in 68 patients, resulting in an LRR of 4.2%, and 182 (11%) patients developed distant metastases. Five-year overall survival was 74% (95% CI: 71.64-75.91).

CONCLUSIONS: Five-year follow-up of curatively treated patients with RC in Denmark revealed a low LRR. This figure is identical to those reported in other Nordic countries, despite Denmark's considerably stricter guidelines for CRT. The obtained results justify the currently adopted restrictive use of preoperative CRT in Denmark.

Original languageEnglish
JournalActa Oncologica
ISSN0284-186X
DOIs
Publication statusPublished - 31 Aug 2018

ID: 55129580