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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Left atrial strain predicts incident atrial fibrillation in the general population: the Copenhagen City Heart Study

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  1. Changes in left atrial structure and function over a decade in the general population

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  2. Usefulness of left atrial strain for predicting incident atrial fibrillation and ischaemic stroke in the general population

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  3. Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography: the Copenhagen City Heart Study

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  4. Echocardiographic predictors of cardiovascular morbidity and mortality in women from the general population

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  1. Measures of left atrial function predict incident heart failure in a low-risk general population: the Copenhagen City Heart Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association between Isometric and Allometric Height-Indexed Left Atrial Size and Atrial Fibrillation

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BACKGROUND: Left atrial (LA) strain parameters have been demonstrated to be valuable predictors of atrial fibrillation (AF) in several patient cohorts. The purpose of this study was to investigate whether LA strain, assessed by two-dimensional speckle-tracking echocardiography, can be used to predict the development of AF in the general population.

METHODS AND RESULTS: This prospective longitudinal study included 4466 participants from the fifth Copenhagen City Heart Study. All participants underwent a health examination, including echocardiographic measurements of LA strain. Participants with prevalent AF at baseline were excluded. The primary endpoint was incident AF. During a median follow-up period of 5.3 years, 154 (4.3%) participants developed AF. In univariable analysis, peak atrial longitudinal strain (PALS), peak atrial contraction strain (PACS), and LA strain during the conduit phase were significantly associated with the development of AF. PALS [hazard ratio (HR) 1.05, 95% confidence interval (CI) (1.03-1.07), P < 0.001, per 1% decrease] and PACS (HR 1.08, 95% CI (1.05-1.12), P < 0.001, per 1% decrease] remained independent predictors of AF in multivariable analysis. In addition, PALS and PACS remained significantly associated with AF development even in participants with normal-sized atria and normal left ventricular (LV) systolic function.

CONCLUSION: In the general population, PALS and PACS independently predict incident AF. These findings remained consistent even in participants with normal-sized LA and normal LV systolic function.

Original languageEnglish
JournalEuropean Heart Journal Cardiovascular Imaging
Volume23
Issue number1
Pages (from-to)52-60
Number of pages9
ISSN1525-2167
DOIs
Publication statusPublished - 18 Dec 2021

Bibliographical note

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.

ID: 71929829