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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Job insecurity and risk of diabetes: a meta-analysis of individual participant data

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  • Jane E Ferrie
  • Marianna Virtanen
  • Markus Jokela
  • Ida E H Madsen
  • Katriina Heikkilä
  • Lars Alfredsson
  • G David Batty
  • Jakob B Bjorner
  • Marianne Borritz
  • Hermann Burr
  • Nico Dragano
  • Marko Elovainio
  • Eleonor I Fransson
  • Anders Knutsson
  • Markku Koskenvuo
  • Aki Koskinen
  • Anne Kouvonen
  • Meena Kumari
  • Martin L Nielsen
  • Maria Nordin
  • Tuula Oksanen
  • Krista Pahkin
  • Jan H Pejtersen
  • Jaana Pentti
  • Paula Salo
  • Martin J Shipley
  • Sakari B Suominen
  • Adam Tabák
  • Töres Theorell
  • Ari Väänänen
  • Jussi Vahtera
  • Peter J M Westerholm
  • Hugo Westerlund
  • Reiner Rugulies
  • Solja T Nyberg
  • Mika Kivimäki
  • IPD-Work Consortium
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BACKGROUND: Job insecurity has been associated with certain health outcomes. We examined the role of job insecurity as a risk factor for incident diabetes.

METHODS: We used individual participant data from 8 cohort studies identified in 2 open-access data archives and 11 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. We calculated study-specific estimates of the association between job insecurity reported at baseline and incident diabetes over the follow-up period. We pooled the estimates in a meta-analysis to produce a summary risk estimate.

RESULTS: The 19 studies involved 140 825 participants from Australia, Europe and the United States, with a mean follow-up of 9.4 years and 3954 incident cases of diabetes. In the preliminary analysis adjusted for age and sex, high job insecurity was associated with an increased risk of incident diabetes compared with low job insecurity (adjusted odds ratio [OR] 1.19, 95% confidence interval [CI] 1.09-1.30). In the multivariable-adjusted analysis restricted to 15 studies with baseline data for all covariates (age, sex, socioeconomic status, obesity, physical activity, alcohol and smoking), the association was slightly attenuated (adjusted OR 1.12, 95% CI 1.01-1.24). Heterogeneity between the studies was low to moderate (age- and sex-adjusted model: I2 = 24%, p = 0.2; multivariable-adjusted model: I2 = 27%, p = 0.2). In the multivariable-adjusted analysis restricted to high-quality studies, in which the diabetes diagnosis was ascertained from electronic medical records or clinical examination, the association was similar to that in the main analysis (adjusted OR 1.19, 95% CI 1.04-1.35).

INTERPRETATION: Our findings suggest that self-reported job insecurity is associated with a modest increased risk of incident diabetes. Health care personnel should be aware of this association among workers reporting job insecurity.

Translated title of the contributionJobusikkerhed og risiko for sukkersyge: en meta-analyse af individuelle deltager-data
Original languageEnglish
JournalCMAJ
Volume188
Issue number17-18
Pages (from-to)E447-E455
ISSN0008-4409
DOIs
Publication statusPublished - Dec 2016

ID: 49207331