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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jøergensen, MT, Brusgaard, K, Novovic, S, Andersen, AM, Hansen, MB, Gerdes, A-M & de Muckadell, OBS 2012, 'Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?', European Journal of Gastroenterology and Hepatology, vol. 24, no. 3, pp. 309-15. https://doi.org/10.1097/MEG.0b013e32834ee5e2

APA

Jøergensen, M. T., Brusgaard, K., Novovic, S., Andersen, A. M., Hansen, M. B., Gerdes, A-M., & de Muckadell, O. B. S. (2012). Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis? European Journal of Gastroenterology and Hepatology, 24(3), 309-15. https://doi.org/10.1097/MEG.0b013e32834ee5e2

CBE

Jøergensen MT, Brusgaard K, Novovic S, Andersen AM, Hansen MB, Gerdes A-M, de Muckadell OBS. 2012. Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?. European Journal of Gastroenterology and Hepatology. 24(3):309-15. https://doi.org/10.1097/MEG.0b013e32834ee5e2

MLA

Jøergensen, Maiken Thyregod et al. "Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?". European Journal of Gastroenterology and Hepatology. 2012, 24(3). 309-15. https://doi.org/10.1097/MEG.0b013e32834ee5e2

Vancouver

Jøergensen MT, Brusgaard K, Novovic S, Andersen AM, Hansen MB, Gerdes A-M et al. Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis? European Journal of Gastroenterology and Hepatology. 2012;24(3):309-15. https://doi.org/10.1097/MEG.0b013e32834ee5e2

Author

Jøergensen, Maiken Thyregod ; Brusgaard, Klaus ; Novovic, Srdan ; Andersen, Anders Møller ; Hansen, Mark Berner ; Gerdes, Anne-Marie ; de Muckadell, Ove Bent Schaffalitzky. / Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?. In: European Journal of Gastroenterology and Hepatology. 2012 ; Vol. 24, No. 3. pp. 309-15.

Bibtex

@article{606b717ee2e84b878db1bbe9345819d0,
title = "Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?",
abstract = "Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background population (c) in a meta-analysis to combine the results with findings in similar investigations worldwide and (d) to evaluate whether patients with SPINK1 mutations had a more severe clinical course.",
keywords = "Acute Disease, Aged, Biological Markers, C-Reactive Protein, Carrier Proteins, Case-Control Studies, Denmark, Female, Humans, Male, Middle Aged, Mutation, Pancreatitis, Prognosis, Prospective Studies",
author = "J{\o}ergensen, {Maiken Thyregod} and Klaus Brusgaard and Srdan Novovic and Andersen, {Anders M{\o}ller} and Hansen, {Mark Berner} and Anne-Marie Gerdes and {de Muckadell}, {Ove Bent Schaffalitzky}",
note = "Author(s): Joergensen, MT (Joergensen, Maiken Thyregod)[ 1 ] ; Brusgaard, K (Brusgaard, Klaus)[ 2 ] ; Novovic, S (Novovic, Srdan)[ 4 ] ; Andersen, AM (Andersen, Anders Moller)[ 4 ] ; Hansen, MB (Hansen, Mark Berner)[ 4,5 ] ; Gerdes, AM (Gerdes, Anne-Marie)[ 2,3 ] ; de Muckadell, OBS (de Muckadell, Ove Bent Schaffalitzky)[ 1 ] 1 ] Univ So Denmark, Dept Med Gastroenterol S, Odense Univ Hosp, DK-5000 Odense C, Denmark [ 2 ] Univ So Denmark, Dept Clin Genet, Odense Univ Hosp, DK-5000 Odense C, Denmark [ 3 ] Univ Copenhagen, Rigshosp, Dept Clin Genet, DK-2100 Copenhagen, Denmark [ 4 ] Univ Copenhagen, Bispebjerg Hosp, Dept Surg K, Copenhagen, Denmark [ 5 ] AstraZeneca Res & Dev, Molndal, Sweden",
year = "2012",
doi = "10.1097/MEG.0b013e32834ee5e2",
language = "English",
volume = "24",
pages = "309--15",
journal = "European Journal of Gastroenterology and Hepatology",
issn = "0954-691X",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

AU - Jøergensen, Maiken Thyregod

AU - Brusgaard, Klaus

AU - Novovic, Srdan

AU - Andersen, Anders Møller

AU - Hansen, Mark Berner

AU - Gerdes, Anne-Marie

AU - de Muckadell, Ove Bent Schaffalitzky

N1 - Author(s): Joergensen, MT (Joergensen, Maiken Thyregod)[ 1 ] ; Brusgaard, K (Brusgaard, Klaus)[ 2 ] ; Novovic, S (Novovic, Srdan)[ 4 ] ; Andersen, AM (Andersen, Anders Moller)[ 4 ] ; Hansen, MB (Hansen, Mark Berner)[ 4,5 ] ; Gerdes, AM (Gerdes, Anne-Marie)[ 2,3 ] ; de Muckadell, OBS (de Muckadell, Ove Bent Schaffalitzky)[ 1 ] 1 ] Univ So Denmark, Dept Med Gastroenterol S, Odense Univ Hosp, DK-5000 Odense C, Denmark [ 2 ] Univ So Denmark, Dept Clin Genet, Odense Univ Hosp, DK-5000 Odense C, Denmark [ 3 ] Univ Copenhagen, Rigshosp, Dept Clin Genet, DK-2100 Copenhagen, Denmark [ 4 ] Univ Copenhagen, Bispebjerg Hosp, Dept Surg K, Copenhagen, Denmark [ 5 ] AstraZeneca Res & Dev, Molndal, Sweden

PY - 2012

Y1 - 2012

N2 - Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background population (c) in a meta-analysis to combine the results with findings in similar investigations worldwide and (d) to evaluate whether patients with SPINK1 mutations had a more severe clinical course.

AB - Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background population (c) in a meta-analysis to combine the results with findings in similar investigations worldwide and (d) to evaluate whether patients with SPINK1 mutations had a more severe clinical course.

KW - Acute Disease

KW - Aged

KW - Biological Markers

KW - C-Reactive Protein

KW - Carrier Proteins

KW - Case-Control Studies

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutation

KW - Pancreatitis

KW - Prognosis

KW - Prospective Studies

U2 - 10.1097/MEG.0b013e32834ee5e2

DO - 10.1097/MEG.0b013e32834ee5e2

M3 - Journal article

C2 - 22228370

VL - 24

SP - 309

EP - 315

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 3

ER -

ID: 36820247