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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

Research output: Contribution to journal › Journal article › Research › peer-review

DOI

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Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background population (c) in a meta-analysis to combine the results with findings in similar investigations worldwide and (d) to evaluate whether patients with SPINK1 mutations had a more severe clinical course.
Original languageEnglish
JournalEuropean Journal of Gastroenterology and Hepatology
Volume24
Issue number3
Pages (from-to)309-15
Number of pages7
ISSN0954-691X
DOIs
Publication statusPublished - 2012

Bibliographical note

Author(s): Joergensen, MT (Joergensen, Maiken Thyregod)[ 1 ] ; Brusgaard, K (Brusgaard, Klaus)[ 2 ] ; Novovic, S (Novovic, Srdan)[ 4 ] ; Andersen, AM (Andersen, Anders Moller)[ 4 ] ; Hansen, MB (Hansen, Mark Berner)[ 4,5 ] ; Gerdes, AM (Gerdes, Anne-Marie)[ 2,3 ] ; de Muckadell, OBS (de Muckadell, Ove Bent Schaffalitzky)[ 1 ]
1 ] Univ So Denmark, Dept Med Gastroenterol S, Odense Univ Hosp, DK-5000 Odense C, Denmark
[ 2 ] Univ So Denmark, Dept Clin Genet, Odense Univ Hosp, DK-5000 Odense C, Denmark
[ 3 ] Univ Copenhagen, Rigshosp, Dept Clin Genet, DK-2100 Copenhagen, Denmark
[ 4 ] Univ Copenhagen, Bispebjerg Hosp, Dept Surg K, Copenhagen, Denmark
[ 5 ] AstraZeneca Res & Dev, Molndal, Sweden

    Research areas

  • Acute Disease, Aged, Biological Markers, C-Reactive Protein, Carrier Proteins, Case-Control Studies, Denmark, Female, Humans, Male, Middle Aged, Mutation, Pancreatitis, Prognosis, Prospective Studies

ID: 36820247