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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Immunosuppressive Environment in Basal Cell Carcinoma: The Role of Regulatory T Cells

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  1. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

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  2. Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process

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  3. Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study

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  1. Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study

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  2. Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma

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  3. Skin Patterning in Psoriasis by Spatial Interactions between Pathogenic Cytokines

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  4. High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

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Interaction between tumour survival tactics and anti-tumour immune response is a major determinant for cancer growth. Regulatory T cells (T-regs) contribute to tumour immune escape, but their role in basal cell carcinoma (BCC) is not understood. The fraction of T-regs among T cells was analysed by immunohistochemistry followed by automated image analysis in facial BCC, peritumoural skin and normal, buttock skin. Quantitative real-time PCR (qRT-PCR) was performed for FOXP3 and cytokines involved in T-reg attraction and T-cell activation. T-regs comprised 45% of CD4-cells surrounding BCC. FOXP3 was highly expressed in BCC, but absent in buttock skin. Unexpectedly, expression of FOXP3 was increased in peritumoural skin, with the FOXP3/CD3 fractions exceeding those of BCC (p?=?0.0065). Transforming growth factor (TGF)-? and T-reg chemokine expression was increased in BCC and peritumoural skin, but not in buttock skin, with expression levels correlating with FOXP3. T-regs are abundantly present both in BCC and in peritumoural skin, mediating an immunosuppressed microenvironment permissive for skin cancer.

Original languageEnglish
JournalActa Dermato-Venereologica
Volume96
Issue number7
Pages (from-to)917-921
Number of pages5
ISSN0001-5555
DOIs
Publication statusPublished - 2 Nov 2016

    Research areas

  • Biopsy, Carcinoma, Basal Cell, Cytokines, Forkhead Transcription Factors, Humans, Immunohistochemistry, Lymphocyte Activation, Real-Time Polymerase Chain Reaction, Skin Neoplasms, T-Lymphocytes, Regulatory, Journal Article

ID: 49765364