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Bispebjerg Hospital - a part of Copenhagen University Hospital

High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

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  • Sarah Mollerup
  • Maria Asplund
  • Jens Friis-Nielsen
  • Kristín Rós Kjartansdóttir
  • Helena Fridholm
  • Thomas Arn Hansen
  • José Alejandro Romero Herrera
  • Christopher James Barnes
  • Randi Holm Jensen
  • Stine Raith Richter
  • Ida Broman Nielsen
  • Carlotta Pietroni
  • David E Alquezar-Planas
  • Alba Rey-Iglesia
  • Pernille V S Olsen
  • Ewa Rajpert-De Meyts
  • Line Groth-Pedersen
  • Christian von Buchwald
  • David H Jensen
  • Robert Gniadecki
  • Estrid Høgdall
  • Jill Levin Langhoff
  • Imre Pete
  • Ildikó Vereczkey
  • Zsolt Baranyai
  • Karen Dybkaer
  • Hans Erik Johnsen
  • Torben Steiniche
  • Peter Hokland
  • Jacob Rosenberg
  • Ulrik Baandrup
  • Thomas Sicheritz-Pontén
  • Eske Willerslev
  • Søren Brunak
  • Ole Lund
  • Tobias Mourier
  • Lasse Vinner
  • Jose M G Izarzugaza
  • Lars Peter Nielsen
  • Anders Johannes Hansen
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BACKGROUND: Viruses and other infectious agents cause more than 15% of human cancer cases. High-throughput sequencing-based studies of virus-cancer associations have mainly focused on cancer transcriptome data.

METHODS: In this study, we applied a diverse selection of presequencing enrichment methods targeting all major viral groups, to characterize the viruses present in 197 samples from 18 sample types of cancerous origin. Using high-throughput sequencing, we generated 710 datasets constituting 57 billion sequencing reads.

RESULTS: Detailed in silico investigation of the viral content, including exclusion of viral artefacts, from de novo assembled contigs and individual sequencing reads yielded a map of the viruses detected. Our data reveal a virome dominated by papillomaviruses, anelloviruses, herpesviruses, and parvoviruses. More than half of the included samples contained 1 or more viruses; however, no link between specific viruses and cancer types were found.

CONCLUSIONS: Our study sheds light on viral presence in cancers and provides highly relevant virome data for future reference.

Original languageEnglish
JournalThe Journal of infectious diseases
Issue number8
Pages (from-to)1312-1324
Number of pages13
Publication statusPublished - 13 Sep 2019

ID: 58288763