Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0-6 years

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Age and weight at final discharge from an early discharge programme for stable but tube-fed preterm infants

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Children and adolescents previously treated with glucocorticoids display lower verbal intellectual abilities

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Poisoning mortality in Danish children and adolescents, 1970-2006 - a registry-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Short-term mortality following tramadol poisonings in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mirtazapine exposure in pregnancy and fetal safety: A nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Drug use in patients with short bowel syndrome and intestinal failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Using soluble urokinase plasminogen activator receptor to stratify patients for medication review in the emergency department

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: To evaluate the prevalence of potentially hepatoxic paracetamol ingestion and associated N-acetylcysteine treatment in young children suspected of paracetamol poisoning.

METHODS: A retrospective cohort study of children aged 0-6 years suspected of paracetamol poisoning with a related plasma-paracetamol measurement in the Capital Region of Denmark in the period 2010-2017. Data from the clinical laboratory system were linked to data from electronic patient records via the unique identification number given to all Danish residents.

RESULTS: Of 297 children included, suspected single paracetamol overdoses were present in 281 (95%). Sixty-nine per cent were treated with N-acetylcysteine, and the mean treatment period was 20.3 h (SD 20.8). A maximum of 6 (2%) of the children suspected of single overdose had plasma-paracetamol concentrations that exceeded the recommended treatment thresholds. No cases of severe hepatotoxicity were registered. Adverse events to N-acetylcysteine-treatment were registered in 3 (2%) children including one anaphylactoid reaction (0.5%).

CONCLUSION: This study shows that initiating N-acetylcysteine as a 'one size fit all' treatment regimen in all children aged 0-6 years with a suspected single paracetamol overdose leads to substantial overtreatment. The data support that it is feasible to initiate N-acetylcysteine within 10 h based on an early plasma-paracetamol test.

Original languageEnglish
JournalActa paediatrica
Volume111
Issue number3
Pages (from-to)667-674
Number of pages8
ISSN1651-2227
DOIs
Publication statusPublished - Mar 2022

Bibliographical note

This article is protected by copyright. All rights reserved.

    Research areas

  • Acetaminophen, Acetylcysteine/therapeutic use, Analgesics, Non-Narcotic, Antidotes/therapeutic use, Child, Child, Preschool, Denmark/epidemiology, Humans, Infant, Infant, Newborn, Retrospective Studies

ID: 69018670