Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital

Grading lumbar disc degeneration: a comparison between low- and high-field MRI

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Tattoo complications and magnetic resonance imaging: a comprehensive review of the literature

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Arterial spin labeling: a technical overview

    Research output: Contribution to journalReviewResearchpeer-review

  1. Perfusion in bone marrow lesions assessed on DCE-MRI and its association with pain in knee osteoarthritis: a cross-sectional study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: More advanced disc degeneration on magnetic resonance imaging (MRI) is found in individuals with low back pain. However, it is unclear whether this grading is independent of the scanner's field strength.

PURPOSE: To compare disc degeneration on high- versus low-field MRI.

MATERIAL AND METHODS: Low back pain patients were enrolled to undergo high-field (3 T) MRI, followed by low-field (0.25 T) MRI of the lumbar spine within 3 h. Three radiologists graded the disc degeneration on Pfirrmann's grading scale with a hiatus of 3 months. A subsample was regraded 6 months later. Reproducibility was measured by weighted kappa statistics (using PROC FREQ statement with AGREE in the TABLES statement for SAS), absolute agreement (i.e. 1:1 agreement/the total number) and the difference in the prevalence (McNemar test).

RESULTS: Moderate to substantial agreement (κ = 0.52-0.62) and absolute agreement of 43.8-66.1% were found between field strengths. Low-field MRI tended to have numerically higher and lower grades than high-field MRI resulting in a significant difference in the prevalence of grades ( p < 0.001). Both field strengths resulted in a moderate to substantial inter-reader agreement (low-field: κ = 0.63, 0.63, 0.54 and high-field: κ = 0.55, 0.43, 0.53) and intra-reader agreement (high-field: κ = 0.57, 0.77, 0.67 and low-field: κ = 0.51, 0.50, 0.70). Only, the reader with the shortest experience had better agreement with high-field compared to low-field.

CONCLUSIONS: There were a significant difference in the prevalence of disc degeneration grading between 0.25 T and 3 T MRI. Therefore, field strength should be taken into consideration when comparing studies using disc degeneration grading as an outcome.

Original languageEnglish
JournalActa Radiologica
Issue number12
Pages (from-to)1636-1642
Number of pages7
Publication statusPublished - Dec 2019

    Research areas

  • Disc degeneration, agreement, low back pain, magnetic fields, magnetic resonance imaging, reliability, Lumbar Vertebrae/diagnostic imaging, Humans, Middle Aged, Intervertebral Disc Degeneration/diagnostic imaging, Magnetic Resonance Imaging/methods, Male, Young Adult, Adolescent, Adult, Female, Aged

ID: 58098420