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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

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DOI

  1. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study

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  1. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association of Birth Weight, Childhood Body Mass Index, and Height With Risk of Hidradenitis Suppurativa

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  3. Atopic dermatitis is associated with increased use of social benefits: a register-based cohort study

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  4. Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

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The aim of this study was to determine age at onset of psoriasis in a population-based twin sample. Questionnaire-data on age at onset of psoriasis in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected. The association between the ages at onset of psoriasis was calculated using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages at onset of psoriasis was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset) = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that age at onset of psoriasis is, in part, genetically determined. The results do not support that early-onset psoriasis is more genetically determined.

Original languageEnglish
JournalActa Dermatovenereologica
Volume96
Issue number1
Pages (from-to)35-38
ISSN0001-5555
DOIs
Publication statusPublished - 2016

ID: 45447742