Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Interethnic analyses of blood pressure loci in populations of East Asian and European descent

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Influence of educational level on test and treatment for incident hypothyroidism

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women: The MORGAM Project

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. På vej mod en sundere og bedre behandlet befolkning?

    Research output: Contribution to journalComment/debateCommunication

  • Tarunveer S Ahluwalia
  • Anders U Eliasen
  • Astrid Sevelsted
  • Casper-Emil T Pedersen
  • Jakob Stokholm
  • Bo Chawes
  • Jette Bork-Jensen
  • Niels Grarup
  • Oluf Pedersen
  • Torben Hansen
  • Allan Linneberg
  • Amitabh Sharma
  • Scott T Weiss
  • Michael D Evans
  • Daniel J Jackson
  • Andreanne Morin
  • Karen A Krogfelt
  • Susanne Schjørring
  • Preben B Mortensen
  • David M Hougaard
  • Jonas Bybjerg-Grauholm
  • Marie Bækvad-Hansen
  • Ole Mors
  • Merete Nordentoft
  • Anders D Børglum
  • Thomas Werge
  • Esben Agerbo
  • James E Gern
  • Robert F Lemanske
  • Carole Ober
  • Anders G Pedersen
  • Hans Bisgaard
  • Klaus Bønnelykke
View graph of relations

Asthma with severe exacerbation is the most common cause of hospitalization among young children. We aim to increase the understanding of this clinically important disease entity through a genome-wide association study. The discovery analysis comprises 2866 children experiencing severe asthma exacerbation between ages 2 and 6 years, and 65,415 non-asthmatic controls, and we replicate findings in 918 children from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) birth cohorts. We identify rs281379 near FUT2/MAMSTR on chromosome 19 as a novel risk locus (OR = 1.18 (95% CI = 1.11-1.25), Pdiscovery = 2.6 × 10-9) as well as a biologically plausible interaction between functional variants in FUT2 and ABO. We further discover and replicate a potential causal mechanism behind this interaction related to S. pneumoniae respiratory illnesses. These results suggest a novel mechanism of early childhood asthma and demonstrates the importance of phenotype-specificity for discovery of asthma genes and epistasis.

Original languageEnglish
Article number6398
JournalNature Communications
Volume11
Issue number1
Pages (from-to)6398
ISSN2041-1723
DOIs
Publication statusPublished - 16 Dec 2020

ID: 61546213