Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Fertility outcomes in asthma: a clinical study of 245 women with unexplained infertility

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Heredity of supraglottic exercise-induced laryngeal obstruction

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Simulator training for endobronchial ultrasound: a randomised controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Low socioeconomic status and lung function

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Airway gene expression identifies subtypes of type 2 inflammation in severe asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM)

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effective clinical study recruitment of patients with atopic dermatitis through social media

    Research output: Contribution to journalLetterResearchpeer-review

  4. Airway hyperresponsiveness to inhaled mannitol identifies a cluster of non-eosinophilic asthma patients with high symptom burden

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Impact of white balance adjustment on evaluation of photographs of atopic dermatitis lesions

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations

Evidence is increasing of an association between asthma and aspects of female reproduction. However, current knowledge is limited and furthermore relies on questionnaire studies or small populations. In a prospective observational cohort study to investigate whether time to pregnancy, the number of fertility treatments, and the number of successful pregnancies differ significantly between women with unexplained infertility with and without asthma.245 women with unexplained infertility (aged 23-45 years) underwent questionnaires and asthma and allergy testing while undergoing fertility treatment. 96 women entering the study had either a former doctor's diagnosis of asthma or were diagnosed with asthma when included. After inclusion they were followed for a minimum of 12 months in fertility treatment, until they had a successful pregnancy, stopped treatment, or the observation ended.The likelihood of achieving pregnancy was lower in women with asthma compared with those without asthma: median total time to pregnancy was 32.3 months in non-asthmatic women versus 55.6 months in those with asthma, hazard ratio 0.50 (95% confidence interval 0.34-0.74) p<0.001.Women with asthma had fewer successful pregnancies during fertility treatment, 39.6 versus 60.4% (p=0.002). Increasing age was of negative importance for expected time to pregnancy, especially among asthmatic women (interaction between age and asthma on time to pregnancy, p=0.001). Female asthmatics had a longer time to pregnancy and less often became pregnant than non-asthmatic women. Increasing age reduced the chances of conceiving especially among asthmatic women. The causal relationship between asthma and subfertility remains unclear.

Original languageEnglish
JournalEuropean Respiratory Journal
Volume47
Issue number4
Pages (from-to)1144-1151
ISSN0903-1936
DOIs
Publication statusPublished - Apr 2016

ID: 46231792