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Bispebjerg Hospital - a part of Copenhagen University Hospital
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European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Research output: Contribution to journalJournal articleResearchpeer-review

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    Research output: Contribution to journalJournal articleResearchpeer-review

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    Research output: Contribution to journalJournal articleResearchpeer-review

  • Emrah Düzel
  • Julio Acosta-Cabronero
  • David Berron
  • Geert Jan Biessels
  • Isabella Björkman-Burtscher
  • Michel Bottlaender
  • Richard Bowtell
  • Mark V Buchem
  • Arturo Cardenas-Blanco
  • Fawzi Boumezbeur
  • Dennis Chan
  • Stuart Clare
  • Mauro Costagli
  • Ludovic de Rochefort
  • Ariane Fillmer
  • Penny Gowland
  • Oskar Hansson
  • Jeroen Hendrikse
  • Oliver Kraff
  • Mark E Ladd
  • Itamar Ronen
  • Esben Petersen
  • James B Rowe
  • Hartwig Siebner
  • Tony Stoecker
  • Sina Straub
  • Michela Tosetti
  • Kamil Uludag
  • Alexandre Vignaud
  • Jaco Zwanenburg
  • Oliver Speck
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Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists.

Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization.

Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials.

Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.

Original languageEnglish
JournalAlzheimer's & dementia (Amsterdam, Netherlands)
Volume11
Pages (from-to)538-549
Number of pages12
ISSN2352-8729
DOIs
Publication statusPublished - 1 Dec 2019

    Research areas

  • Alzheimer's disease (AD), Magnetic resonance imaging (MRI), Mild cognitive impairment (MCI), Parkinson's disease (PD), Subjective cognitive decline (SCD), Ultrahigh-field MRI, Vascular dementia

ID: 57728299