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Effects of exercise training and IL-6 receptor blockade on gastric emptying and GLP-1 secretion in obese humans: Secondary Analyses From a Double Blind Randomized Clinical Trial

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Lehrskov, LL, Christensen, RH, Wedell-Neergaard, A-S, Legaard, GE, Dorph, E, Larsen, MK, Henneberg, M, Launbo, N, Fagerlind, SR, Seide, SK, Nymand, S, Ball, M, Vinum, N, Dahl, C, Wewer Albrechtsen, NJ, Holst, JJ, Ried-Larsen, M, Rosenmeier, JB, Krogh-Madsen, R, Karstoft, K, Pedersen, BK & Ellingsgaard, H 2019, 'Effects of exercise training and IL-6 receptor blockade on gastric emptying and GLP-1 secretion in obese humans: Secondary Analyses From a Double Blind Randomized Clinical Trial' Frontiers in physiology, vol. 10, 1249. https://doi.org/10.3389/fphys.2019.01249

APA

CBE

Lehrskov LL, Christensen RH, Wedell-Neergaard A-S, Legaard GE, Dorph E, Larsen MK, Henneberg M, Launbo N, Fagerlind SR, Seide SK, Nymand S, Ball M, Vinum N, Dahl C, Wewer Albrechtsen NJ, Holst JJ, Ried-Larsen M, Rosenmeier JB, Krogh-Madsen R, Karstoft K, Pedersen BK, Ellingsgaard H. 2019. Effects of exercise training and IL-6 receptor blockade on gastric emptying and GLP-1 secretion in obese humans: Secondary Analyses From a Double Blind Randomized Clinical Trial. Frontiers in physiology. 10. https://doi.org/10.3389/fphys.2019.01249

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Author

Lehrskov, Louise Lang ; Christensen, Regitse Højgaard ; Wedell-Neergaard, Anne-Sophie ; Legaard, Grit Elster ; Dorph, Emma ; Larsen, Monica Korsager ; Henneberg, Marie ; Launbo, Natja ; Fagerlind, Sabrina Ravn ; Seide, Sidsel Kofoed ; Nymand, Stine ; Ball, Maria ; Vinum, Nicole ; Dahl, Camilla ; Wewer Albrechtsen, Nicolai Jacob ; Holst, Jens Juul ; Ried-Larsen, Mathias ; Rosenmeier, Jaya Birgitte ; Krogh-Madsen, Rikke ; Karstoft, Kristian ; Pedersen, Bente Klarlund ; Ellingsgaard, Helga. / Effects of exercise training and IL-6 receptor blockade on gastric emptying and GLP-1 secretion in obese humans : Secondary Analyses From a Double Blind Randomized Clinical Trial. In: Frontiers in physiology. 2019 ; Vol. 10.

Bibtex

@article{6185a3bebf0f4ae4a872dad52017b7f7,
title = "Effects of exercise training and IL-6 receptor blockade on gastric emptying and GLP-1 secretion in obese humans: Secondary Analyses From a Double Blind Randomized Clinical Trial",
abstract = "Background: Interleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we investigate whether repeated increases in IL-6, induced by exercise training, influence gastric emptying rate and moreover if IL-6 is required for exercise-induced adaptations in glycemic control including secretion of glucagon and glucagon-like peptide-1 (GLP-1).Methods: A total of 52 abdominally obese non-diabetic men and women were randomly assigned into four groups performing 12 weeks of endurance exercise or no exercise with or without IL-6 receptor blockade (tocilizumab). The primary endpoint was change in gastric emptying rate in response to the intervention and other endpoints included changes in glycemic control, glucagon, and GLP-1 secretion.Results: There was no change in gastric emptying rate in any of the four groups following the intervention and comparing differences in change between groups also revealed no difference. Postprandial glucose remained unchanged in all groups but the exercise + tocilizumab group, which improved postprandial glucose in response to the intervention. The area under the curve for meal-stimulated glucagon, active and total GLP-1 increased in response to IL-6 receptor blockade, this effect was independent of exercise.Conclusion: Exercise training and long-term IL-6 receptor blockade did not change gastric emptying rates in obese humans. IL-6 receptor blockade increased glucagon and GLP-1 secretion and implicate IL-6 in the regulation of the human alpha and L cells.",
keywords = "GLP-1, exercise, gastric emptying, glucagon, interleukin-6, tocilizumab",
author = "Lehrskov, {Louise Lang} and Christensen, {Regitse H{\o}jgaard} and Anne-Sophie Wedell-Neergaard and Legaard, {Grit Elster} and Emma Dorph and Larsen, {Monica Korsager} and Marie Henneberg and Natja Launbo and Fagerlind, {Sabrina Ravn} and Seide, {Sidsel Kofoed} and Stine Nymand and Maria Ball and Nicole Vinum and Camilla Dahl and {Wewer Albrechtsen}, {Nicolai Jacob} and Holst, {Jens Juul} and Mathias Ried-Larsen and Rosenmeier, {Jaya Birgitte} and Rikke Krogh-Madsen and Kristian Karstoft and Pedersen, {Bente Klarlund} and Helga Ellingsgaard",
note = "Copyright {\circledC} 2019 Lang Lehrskov, Christensen, Wedell-Neergaard, Legaard, Dorph, Larsen, Henneberg, Launbo, Fagerlind, Seide, Nymand, Ball, Vinum, Dahl, Wewer Albrechtsen, Holst, Ried-Larsen, Rosenmeier, Krogh-Madsen, Karstoft, Pedersen and Ellingsgaard.",
year = "2019",
month = "10",
day = "4",
doi = "10.3389/fphys.2019.01249",
language = "English",
volume = "10",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Effects of exercise training and IL-6 receptor blockade on gastric emptying and GLP-1 secretion in obese humans

T2 - Secondary Analyses From a Double Blind Randomized Clinical Trial

AU - Lehrskov, Louise Lang

AU - Christensen, Regitse Højgaard

AU - Wedell-Neergaard, Anne-Sophie

AU - Legaard, Grit Elster

AU - Dorph, Emma

AU - Larsen, Monica Korsager

AU - Henneberg, Marie

AU - Launbo, Natja

AU - Fagerlind, Sabrina Ravn

AU - Seide, Sidsel Kofoed

AU - Nymand, Stine

AU - Ball, Maria

AU - Vinum, Nicole

AU - Dahl, Camilla

AU - Wewer Albrechtsen, Nicolai Jacob

AU - Holst, Jens Juul

AU - Ried-Larsen, Mathias

AU - Rosenmeier, Jaya Birgitte

AU - Krogh-Madsen, Rikke

AU - Karstoft, Kristian

AU - Pedersen, Bente Klarlund

AU - Ellingsgaard, Helga

N1 - Copyright © 2019 Lang Lehrskov, Christensen, Wedell-Neergaard, Legaard, Dorph, Larsen, Henneberg, Launbo, Fagerlind, Seide, Nymand, Ball, Vinum, Dahl, Wewer Albrechtsen, Holst, Ried-Larsen, Rosenmeier, Krogh-Madsen, Karstoft, Pedersen and Ellingsgaard.

PY - 2019/10/4

Y1 - 2019/10/4

N2 - Background: Interleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we investigate whether repeated increases in IL-6, induced by exercise training, influence gastric emptying rate and moreover if IL-6 is required for exercise-induced adaptations in glycemic control including secretion of glucagon and glucagon-like peptide-1 (GLP-1).Methods: A total of 52 abdominally obese non-diabetic men and women were randomly assigned into four groups performing 12 weeks of endurance exercise or no exercise with or without IL-6 receptor blockade (tocilizumab). The primary endpoint was change in gastric emptying rate in response to the intervention and other endpoints included changes in glycemic control, glucagon, and GLP-1 secretion.Results: There was no change in gastric emptying rate in any of the four groups following the intervention and comparing differences in change between groups also revealed no difference. Postprandial glucose remained unchanged in all groups but the exercise + tocilizumab group, which improved postprandial glucose in response to the intervention. The area under the curve for meal-stimulated glucagon, active and total GLP-1 increased in response to IL-6 receptor blockade, this effect was independent of exercise.Conclusion: Exercise training and long-term IL-6 receptor blockade did not change gastric emptying rates in obese humans. IL-6 receptor blockade increased glucagon and GLP-1 secretion and implicate IL-6 in the regulation of the human alpha and L cells.

AB - Background: Interleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we investigate whether repeated increases in IL-6, induced by exercise training, influence gastric emptying rate and moreover if IL-6 is required for exercise-induced adaptations in glycemic control including secretion of glucagon and glucagon-like peptide-1 (GLP-1).Methods: A total of 52 abdominally obese non-diabetic men and women were randomly assigned into four groups performing 12 weeks of endurance exercise or no exercise with or without IL-6 receptor blockade (tocilizumab). The primary endpoint was change in gastric emptying rate in response to the intervention and other endpoints included changes in glycemic control, glucagon, and GLP-1 secretion.Results: There was no change in gastric emptying rate in any of the four groups following the intervention and comparing differences in change between groups also revealed no difference. Postprandial glucose remained unchanged in all groups but the exercise + tocilizumab group, which improved postprandial glucose in response to the intervention. The area under the curve for meal-stimulated glucagon, active and total GLP-1 increased in response to IL-6 receptor blockade, this effect was independent of exercise.Conclusion: Exercise training and long-term IL-6 receptor blockade did not change gastric emptying rates in obese humans. IL-6 receptor blockade increased glucagon and GLP-1 secretion and implicate IL-6 in the regulation of the human alpha and L cells.

KW - GLP-1

KW - exercise

KW - gastric emptying

KW - glucagon

KW - interleukin-6

KW - tocilizumab

UR - http://www.scopus.com/inward/record.url?scp=85073694530&partnerID=8YFLogxK

U2 - 10.3389/fphys.2019.01249

DO - 10.3389/fphys.2019.01249

M3 - Journal article

VL - 10

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 1249

ER -

ID: 58225586