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Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

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@article{d9bc3bb570f34697aee6987c918528d5,
title = "Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling",
abstract = "Overloading of tendon tissue with resulting chronic pain (tendinopathy) is a common disorder in occupational-, leisure- and sports-activity, but its pathogenesis remains poorly understood. To investigate the very early phase of tendinopathy, Achilles and patellar tendons were investigated in 200 physically active patients and 50 healthy control persons. Patients were divided into three groups: symptoms for 0-1 months (T1), 1-2 months (T2) or 2-3 months (T3). Tendinopathic Achilles tendon cross-sectional area determined by ultrasonography (US) was ~25% larger than in healthy control persons. Both Achilles and patellar anterior-posterior diameter were elevated in tendinopathy, and only later in Achilles was the width increased. Increased tendon size was accompanied by an increase in hypervascularization (US Doppler flow) without any change in mRNA for angiogenic factors. From patellar biopsies taken bilaterally, mRNA for most growth factors and tendon components remained unchanged (except for TGF-beta1 and substance-P) in early tendinopathy. Tendon stiffness remained unaltered over the first three months of tendinopathy and was similar to the asymptomatic contra-lateral tendon. In conclusion, this suggests that tendinopathy pathogenesis represents a disturbed tissue homeostasis with fluid accumulation. The disturbance is likely induced by repeated mechanical overloading rather than a partial rupture of the tendon.",
keywords = "clinical, inflammation, mRNA, tendinopathy, ultrasound",
author = "Tran, {Peter H T} and Malmgaard-Clausen, {Nikolaj M} and Puggaard, {Rikke S} and Svensson, {Ren{\'e} B} and Nybing, {Janus D} and Philip Hansen and Peter Schjerling and Zinglersen, {Amanda H} and Christian Coupp{\'e} and Mikael Boesen and Magnusson, {S Peter} and Michael Kjaer",
note = "{\textcopyright} 2019 Federation of American Societies for Experimental Biology.",
year = "2020",
month = jan,
doi = "10.1096/fj.201901309R",
language = "English",
volume = "34",
pages = "776--788",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",
number = "1",

}

RIS

TY - JOUR

T1 - Early development of tendinopathy in humans

T2 - Sequence of pathological changes in structure and tissue turnover signaling

AU - Tran, Peter H T

AU - Malmgaard-Clausen, Nikolaj M

AU - Puggaard, Rikke S

AU - Svensson, René B

AU - Nybing, Janus D

AU - Hansen, Philip

AU - Schjerling, Peter

AU - Zinglersen, Amanda H

AU - Couppé, Christian

AU - Boesen, Mikael

AU - Magnusson, S Peter

AU - Kjaer, Michael

N1 - © 2019 Federation of American Societies for Experimental Biology.

PY - 2020/1

Y1 - 2020/1

N2 - Overloading of tendon tissue with resulting chronic pain (tendinopathy) is a common disorder in occupational-, leisure- and sports-activity, but its pathogenesis remains poorly understood. To investigate the very early phase of tendinopathy, Achilles and patellar tendons were investigated in 200 physically active patients and 50 healthy control persons. Patients were divided into three groups: symptoms for 0-1 months (T1), 1-2 months (T2) or 2-3 months (T3). Tendinopathic Achilles tendon cross-sectional area determined by ultrasonography (US) was ~25% larger than in healthy control persons. Both Achilles and patellar anterior-posterior diameter were elevated in tendinopathy, and only later in Achilles was the width increased. Increased tendon size was accompanied by an increase in hypervascularization (US Doppler flow) without any change in mRNA for angiogenic factors. From patellar biopsies taken bilaterally, mRNA for most growth factors and tendon components remained unchanged (except for TGF-beta1 and substance-P) in early tendinopathy. Tendon stiffness remained unaltered over the first three months of tendinopathy and was similar to the asymptomatic contra-lateral tendon. In conclusion, this suggests that tendinopathy pathogenesis represents a disturbed tissue homeostasis with fluid accumulation. The disturbance is likely induced by repeated mechanical overloading rather than a partial rupture of the tendon.

AB - Overloading of tendon tissue with resulting chronic pain (tendinopathy) is a common disorder in occupational-, leisure- and sports-activity, but its pathogenesis remains poorly understood. To investigate the very early phase of tendinopathy, Achilles and patellar tendons were investigated in 200 physically active patients and 50 healthy control persons. Patients were divided into three groups: symptoms for 0-1 months (T1), 1-2 months (T2) or 2-3 months (T3). Tendinopathic Achilles tendon cross-sectional area determined by ultrasonography (US) was ~25% larger than in healthy control persons. Both Achilles and patellar anterior-posterior diameter were elevated in tendinopathy, and only later in Achilles was the width increased. Increased tendon size was accompanied by an increase in hypervascularization (US Doppler flow) without any change in mRNA for angiogenic factors. From patellar biopsies taken bilaterally, mRNA for most growth factors and tendon components remained unchanged (except for TGF-beta1 and substance-P) in early tendinopathy. Tendon stiffness remained unaltered over the first three months of tendinopathy and was similar to the asymptomatic contra-lateral tendon. In conclusion, this suggests that tendinopathy pathogenesis represents a disturbed tissue homeostasis with fluid accumulation. The disturbance is likely induced by repeated mechanical overloading rather than a partial rupture of the tendon.

KW - clinical

KW - inflammation

KW - mRNA

KW - tendinopathy

KW - ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85077741381&partnerID=8YFLogxK

U2 - 10.1096/fj.201901309R

DO - 10.1096/fj.201901309R

M3 - Journal article

C2 - 31914656

VL - 34

SP - 776

EP - 788

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 1

ER -

ID: 59117375