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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Drug-related challenges following primary total hip and knee arthroplasty

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DOI

  1. Validation of registration of pharmacological treatment in the Danish Hip and Knee Arthroplasty Registers

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  3. How patients in Denmark acquire their medicines: overview, data sources and implications for pharmacoepidemiology

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  4. Active chlordiazepoxide metabolites in a patient needing life support after treatment of alcohol abstinence

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  1. Collection and Reporting of Patient-reported Outcome Measures in Arthroplasty Registries: Multinational Survey and Recommendations

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Thromboembolic and bleeding complications following primary total knee arthroplasty: a Danish nationwide cohort study

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  3. Using machine learning for predicting intensive care unit resource use during the COVID-19 pandemic in Denmark

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  4. Duloxetine Exposure During Pregnancy and the Risk of Spontaneous and Elective Abortion: A Danish Nationwide Observational Study

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We aimed to characterize the in-hospital analgesic use among total hip or knee arthroplasty (THA or TKA) patients, and to identify possible drug-related challenges. We identified 15 263 patients operated with a THA or TKA between 1 January 2012 and 30 April 2016. The prevalence of analgesic users and patients with potential clinically relevant drug-drug interactions (DDIs), along with the prevalence of readmission among patients with vs. without a DDI, were calculated. A DDI was defined as the combination of (A) a diuretic, an angiotensin-converting enzyme inhibitor or an angiotensin II receptor blocker, and an non-steroidal anti-inflammatory Drug (NSAID); (B) warfarin and an NSAID; and (C) a benzodiazepine or a benzodiazepine-related drug and an opioid. The prevalence of analgesics administered in THA and TKA patients was 99.3% and 99.1% for paracetamol and 93.8% and 98.8% for opioids, respectively. The prevalence of patients who received interaction A, B or C was 8.4%, 2.5% and 40.7%, respectively. Patients with vs. without a DDI had a higher prevalence of 30-day readmission. In conclusion, most THA and TKA patients were administered paracetamol or opioids. The prevalence of 30-day readmission was higher in patients with than in patients without a potential clinically relevant DDI.

Original languageEnglish
JournalBasic & clinical pharmacology & toxicology
Volume129
Issue number2
Pages (from-to)139-147
Number of pages9
ISSN1742-7843
DOIs
Publication statusPublished - Aug 2021

    Research areas

  • analgesic drugs, drug interactions, inappropriate prescriptions, total hip replacement, total knee replacement

ID: 65746339