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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Drug use in patients with short bowel syndrome and intestinal failure

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INTRODUCTION: In patients with short bowel syndrome (SBS), severe malabsorption may cause a need for parenteral support and, by definition, these patients suffer from SBS intestinal failure. Absorption of oral medications is likely diminished in patients with SBS intestinal failure and higher than normal doses may be required to achieve sufficient pharmacologic effect. We investigated the prescription patterns and oral dosages in a well-defined population of patients with non-malignant SBS intestinal failure.

METHODS: This was a cross-sectional analysis based on a cohort of adult patients with SBS intestinal failure treated with home parenteral support and registered in 2016 at the Department of Gastroenterology at the Copenhagen University Hospital - Rigshospitalet. The patients' clinical data and prescription patterns were extracted from electronic medical and medications records.

RESULTS: The patients in our cohort (n = 74) were primarily females (58%), the median age was 63 years (interquartile range (IQR): 52-72 years) and the median BMI was 22 kg/m2 (IQR: 19-26 kg/m2). Each patient was treated with a median of eight drugs (range: 1-20). Most (75%) of the medications were administered orally. Only codeine, levothyroxine and loperamide were prescribed in higher dosages than recommended in their product labelling. All medication-treated patients were prescribed between one and four different analgesics.

CONCLUSION: In our single-centre cohort of patients with SBS intestinal failure, orally administered medications were generally prescribed in recommended dosages.

FUNDING: none Trial registration. Approved by the Danish Data Protection Agency (BFH-2016-058, I-Suite no.: 04906) and the Danish Patient Safety Authority (3-3013-1884/1/).

Original languageEnglish
JournalDanish Medical Journal
Volume69
Issue number5
ISSN1603-9629
Publication statusPublished - 28 Apr 2022

Bibliographical note

Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

    Research areas

  • Adult, Cohort Studies, Cross-Sectional Studies, Female, Humans, Intestinal Failure, Middle Aged, Parenteral Nutrition, Short Bowel Syndrome/drug therapy

ID: 77899181